Harnessing open-source technology for low-cost automation in synthesis: Flow chemical deprotection of silyl ethers using a homemade autosampling system

TETRAHEDRON LETTERS

卷:58

Article

O'Brien, Matthew¹  Konings, Lisette^1,2  Martin, Matthew¹  Heap, Jordan¹ 

[1] Keele Univ, Sch Chem & Phys Sci, Lennard Jones Labs, Borough Of Newcastle Und ST5 5BG, Staffs, England

[2] Avans Univ Appl Sci, Lovensdijkstr 61-63, NL-4818 AJ Breda, North Brabant, Netherlands

关键词: Open-source;    Automation;    Flow chemistry;    Desilylation;    Liquid-liquid extraction;   

DOI  :  10.1016/j.tetlet.2017.05.008

来源: Elsevier

【 摘 要 】

An inexpensive homemade 3-axis autosampler was used to facilitate the automation of an acid catalysed flow chemical desilylation reaction. Harnessing open-source software technologies (Python, OpenCV), an automated computer-vision controlled liquid-liquid extraction step was used to provide effective inline purification. A Raspberry Pi single-board computer was employed to interface with the motors used in the autosampler and actuated fluidic valves. (C) 2017 Elsevier Ltd. All rights reserved.

【 授权许可】

Free