An efficient, three-component synthesis of isoindolin-1-one-3-phosphonates under mild and solvent-free conditions

TETRAHEDRON LETTERS

卷:57

Article

Adib, Mehdi¹  Sheikhi, Ehsan¹  Yazzaf, Rozita¹  Bijanzadeh, Hamid Reza²  Mirzaei, Peiman³ 

[1] Univ Tehran, Coll Sci, Sch Chem, POB 14155-6455, Tehran, Iran

[2] Tarbiat Modares Univ, Dept Chem, Tehran, Iran

[3] Shahid Beheshti Univ, Dept Chem, Tehran, Iran

关键词: Multi-component reactions;    Isoindolin-l-one-3-phosphonates;    2-Formylbenzoic acids;    Primary amines;    Trialkyl phosphites;    Solvent-free synthesis;   

DOI  :  10.1016/j.tetlet.2015.12.055

来源: Elsevier

【 摘 要 】

An efficient and mild three-component synthesis of isoindolin-1-one-3-phosphonates is described. The reaction between a 2-formylbenzoic acid, a primary amine, and a trialkyl phosphite proceeded at ambient temperature under catalyst-and solvent-free conditions to afford the desired compounds in excellent yields. (C) 2015 Elsevier Ltd. All rights reserved.

【 授权许可】

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