期刊论文详细信息
Bulletin of the Korean chemical society
Four-Component Synthesis of 2-(N,N-Dialkylamino)-2,4,6-Cycloheptatrien-1-One Derivatives from Tropolone, an Isocyanide, a Primary Amine and an Aldehyde via Ugi-Smiles Coupling Reaction
Issa Amini1  Yavar Ahmadi1  Ali Ramazani1  Fatemeh Zeinali Nasrabadi1  Abdolhossain Massoudi1 
关键词: Tropolone;    Isocyanides;    Primary amines;    Aldehydes;    Ugi-Smiles-type reaction;   
DOI  :  
学科分类:化学(综合)
来源: Korean Chemical Society
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【 摘 要 】

The use of Smiles rearrangement in Ugi-type couplings with tropolone allows very straightforward multicomponent formation of 2-(N,N-dialkylamino)-2,4,6-cycloheptatrien-1-one derivatives. The Ugi four-component reaction of isocyanides with tropolone (2-hydroxy-2,4,6-cycloheptatrien-1-one), primary amines and aldehydes proceeds smoothly and cleanly under mild conditions to afford 2-(N,N-dialkylamino)-2,4,6-cycloheptatrien- 1-one derivatives in fairly good yields.

【 授权许可】

Unknown   

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