Highly regioselective 1,3-dipolar cycloaddition of 3′-O-propargyl guanosine with nitrile oxide: An efficient method for the synthesis of guanosine containing isoxazole moiety

TETRAHEDRON LETTERS

卷:61

Article

Shanmugasundaram, Muthian¹  Senthilvelan, Annamalai¹  Kore, Anilkumar R.¹ 

[1] Thermo Fisher Sci, Life Sci Solut Grp, 2130 Woodward St, Austin, TX 78744 USA

关键词: Guanosine;    Nitrile oxide;    Regioselective;    1,3-Dipolar cycloaddition;   

DOI  :  10.1016/j.tetlet.2020.152464

来源: Elsevier

【 摘 要 】

The 1,3-dipolar cycloaddition reaction of 3 '-O-propargyl guanosine with various in-situ generated nitrile oxides in the presence of DMF as a solvent is described. It is noteworthy that the reaction is highly regioselective that affords biologically important guanosine containing isoxazole moiety in good yields with high purities. (C) 2020 Elsevier Ltd. All rights reserved.

【 授权许可】

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