Convenient modular construction of medicinally important 5-acylamino-4,5-dihydroisoxazoles featuring four elements of diversity

TETRAHEDRON LETTERS

卷:57

Article

Kulyashova, Alexandra¹  Krasavin, Mikhail¹ 

[1] St Petersburg State Univ, 7-9 Univ Skaya Nab, St Petersburg 199034, Russia

关键词: Enamide;    Nitrile oxide;    1,3-Dipolar cycloaddition;    Modular synthesis;    Multicomponent reactions;    Isoxazolines;    Privileged structures;   

DOI  :  10.1016/j.tetlet.2016.08.059

来源: Elsevier

【 摘 要 】

An efficient modular approach toward medicinally important 5-acylamino-4,5-isoxazolines via the 1,3-dipolar cycloaddition reaction of nitrile oxides and MCR-derived enamide building blocks is described. This approach results in isoxazolines containing four elements of diversity utilizing two practically simple synthetic operations. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free