An efficient synthesis of styryl 1,3,4-thiadiazoles using Lawesson’s reagent and Propylphosphonic anhydride-precursors for bis heterocycles

Arabian Journal of Chemistry

关键词: Nitrile imine;    Nitrile oxide;    Manganese dioxide;    Pyrazolyl thiadiazole;    Isoxazolyl thiadiazole;   

DOI  :  10.1016/j.arabjc.2014.08.013

来源: DOAJ

【 摘 要 】

The compounds styryl 1,3,4-thiadiazoles were prepared adopting one and two step methodologies to optimize the yield of the products. The two-step methodology via benzohydrazide followed by treatment with Lawesson’s reagent in the presence of Propylphosphonic anhydride and triethylamine produced styryl 1,3,4-thiadiazoles in excellent yields. The olefin moiety in these compounds is utilized to develop pyrazole and isoxazole rings by 1,3-dipolar cycloaddition methodology followed by oxidation.

【 授权许可】

Unknown