Potential application of peripheral blood biomarkers in intracranial aneurysms

Frontiers in Neurology

Neurology

Lijuan Zhang¹  Yangying Wu¹  Ziya Zhao¹  Fajin Lv¹  Shaolei Kang² 

[1] Department of Radiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China;Department of Radiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China;The Department of Medical Imaging, The First Affiliated Hospital of Kunming Medical University, Kunming, China;

关键词: blood biomarker;    intracranial aneurysm;    inflammation;    cytokine;    blood lipid;   

DOI  :  10.3389/fneur.2023.1273341

 received in 2023-08-06, accepted in 2023-10-05,  发布年份 2023

来源: Frontiers

【 摘 要 】

Intracranial aneurysm (IA) counts are increasing yearly, with a high mortality and disability after rupture. Current diagnosis and treatment rely on costly equipment, lacking effective indicators for progression prediction and specific drugs for treatment. Recently, peripheral blood biomarkers, as common clinical test samples, reflecting the immune and inflammatory state of the body in real-time, have shown promise in providing additional information for risk stratification and treatment in IA patients, which may improve their outcomes after aneurysm rupture through anti-inflammatory therapy. Therefore, this paper reviewed the progress of potential biomarkers of IAs, including inflammatory blood indicators, cytokines, and blood lipids, aiming to aid individual management and therapy of aneurysms in clinical practices.

【 授权许可】

Unknown   
Copyright © 2023 Wu, Zhao, Kang, Zhang and Lv.