Biology of Saccular Cerebral Aneurysms: A Review of Current Understanding and Future Directions

Frontiers in Surgery

Vernard S. Fennell¹ 

关键词: biology;    inflammation;    intracranial aneurysm;   

DOI  :  10.3389/fsurg.2016.00043

学科分类：外科医学

来源: Frontiers

【 摘 要 】

Understanding the biology of intracranial aneurysms is a clinical quandary. How these aneurysms form, progress, and rupture is poorly understood. Evidence indicates that well-established risk factors play a critical role, along with immunologic factors, in their development and clinical outcomes. Much of the expanding knowledge of the inception, progression, and rupture of intracranial aneurysms implicates inflammation as a critical mediator of aneurysm pathogenesis. Thus, therapeutic targets exploiting this arm of aneurysm pathogenesis have been implemented, often with promising outcomes.

【 授权许可】

CC BY