Harnessing mechanical cues in the cellular microenvironment for bone regeneration

Frontiers in Physiology

Physiology

Timothy O. Josephson¹  Elise F. Morgan² 

[1] Biomedical Engineering, Boston University, Boston, MA, United States;Center for Multiscale and Translational Mechanobiology, Boston University, Boston, MA, United States;Biomedical Engineering, Boston University, Boston, MA, United States;Center for Multiscale and Translational Mechanobiology, Boston University, Boston, MA, United States;Mechanical Engineering, Boston University, Boston, MA, United States;

关键词: bone;    mechanobiology;    marrow stromal cells (MSCs);    mechanical microenvironment;    osteogenesis;   

DOI  :  10.3389/fphys.2023.1232698

 received in 2023-06-01, accepted in 2023-09-25,  发布年份 2023

来源: Frontiers

【 摘 要 】

At the macroscale, bones experience a variety of compressive and tensile loads, and these loads cause deformations of the cortical and trabecular microstructure. These deformations produce a variety of stimuli in the cellular microenvironment that can influence the differentiation of marrow stromal cells (MSCs) and the activity of cells of the MSC lineage, including osteoblasts, osteocytes, and chondrocytes. Mechanotransduction, or conversion of mechanical stimuli to biochemical and biological signals, is thus part of a multiscale mechanobiological process that drives bone modeling, remodeling, fracture healing, and implant osseointegration. Despite strong evidence of the influence of a variety of mechanical cues, and multiple paradigms proposed to explain the influence of these cues on tissue growth and differentiation, even a working understanding of how skeletal cells respond to the complex combinations of stimuli in their microenvironments remains elusive. This review covers the current understanding of what types of microenvironmental mechanical cues MSCs respond to and what is known about how they respond in the presence of multiple such cues. We argue that in order to realize the vast potential for harnessing the cellular microenvironment for the enhancement of bone regeneration, additional investigations of how combinations of mechanical cues influence bone regeneration are needed.

【 授权许可】

Unknown   
Copyright © 2023 Josephson and Morgan.