期刊论文详细信息
Frontiers in Ecology and Evolution
Annual short-burst mass anthelmintic administration reduces tuberculosis severity but not prevalence in a wildlife reservoir
Ecology and Evolution
Joaquim Segalés1  Pedro Fernández-Llario2  Pilar Gonçalves2  Waldo L. García2  David Risco3  Joanne Lello4  Diana Gassó5  Gregorio Mentaberre5  Irene Torres-Blas6  Jorge R. López-Olvera6  Roser Velarde6  Emmanuel Serrano6  Cristina Garrido-Amaro6 
[1] Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, Barcelona, Spain;Departamento de Sanitat i d’Anatomia Animals, Universitat Autònoma de Barcelona, Barcelona, Spain;Innovación en Gestión y Conservación de Ungulados S.L. (INGULADOS), Cáceres, Spain;Innovación en Gestión y Conservación de Ungulados S.L. (INGULADOS), Cáceres, Spain;Departamento de Medicina Animal, Faculta de Veterinaria, Universidad de Extremadura, Cáceres, Spain;School of Biosciences, Cardiff University, Cardiff, United Kingdom;Wildlife Ecology & Health Group (WE&H) and Departament de Ciència Animal, Escola Tècnica Superior d’Enginyeria Agroalimentaria i Forestal i de Vetarinària (ETSEAFIV), Universitat de Lleida (UdL), Lleida, Spain;Wildlife Ecology and Health Group (WE&H), and Servei d’ Ecopatologia de Fauna Salvatge (SEFaS), Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain;
关键词: bovine tuberculosis;    ivermectin;    helminths;    coinfection;    Mycobacterium bovis;    Sus scrofa;   
DOI  :  10.3389/fevo.2023.1186295
 received in 2023-03-14, accepted in 2023-09-25,  发布年份 2023
来源: Frontiers
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【 摘 要 】

IntroductionTuberculosis (TB), caused by the Mycobacterium tuberculosis complex (MTC), is an important disease in both human and animal systems. Helminths are commonly found in coinfection with MTC and TB is often exacerbated in such coinfections. Long-term anthelmintic administration, to control helminths, can improve a host’s ability to control MTC infection. Mass drug administration programmes, in which anthelmintics are given only once or twice a year, leaving periods where helminth reinfection can occur, are common in both human and domestic animal populations. To date, the effect of such intermittent control programmes on MTC infection and severity has not been explored.MethodsHere we investigate the consequences of a ten-day, annual, mass ivermectin administration on TB prevalence and severity in free-ranging juvenile and yearling (<2 years) wild boar (Sus scrofa).ResultsThis single annual anthelmintic treatment administered over six years reduced TB severity. Further, the proportion of wild boar with severe TB continued to decrease with successive treatments. TB prevalence, however, did not decrease significantly over the course of the study.DiscussionWhile ivermectin has direct anti-mycobacterial effects in vitro, the short duration of treatment means that the reduction in TB severity we observe in wild boar is unlikely to be accounted for by such a direct mechanism. Disruption of the helminth community and subsequent modification or enhancement of the host immune response is a potential mechanism. Future work should examine the consequences of annual anthelmintic drug administration on helminth community composition and structure and on the host immunological responses through time.

【 授权许可】

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Copyright © 2023 Lello, Gassó, Gonçalves, Risco, García, Segalés, Garrido-Amaro, Mentaberre, Torres-Blas, Velarde, López-Olvera, Fernández-Llario and Serrano

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