Children coinfected with multiple respiratory viruses in Pittsburgh schools

Respiratory viruses;coinfection;Epidemiology

Johnson, Jordan AllenCummings, Derek A. T. ;

Johns Hopkins University

关键词: Respiratory viruses;    coinfection;    Epidemiology;   

Others  :  https://jscholarship.library.jhu.edu/bitstream/handle/1774.2/38044/JOHNSON-THESIS-2015.pdf?sequence=1&isAllowed=y

瑞士|英语

来源: JOHNS HOPKINS DSpace Repository

【 摘 要 】

Respiratory diseases cause widespread morbidity and mortality around the globe, particularly among young children and infants. With the rise of effective vaccines against some forms of pneumonia-causing bacteria, it is possible that viral infections may cause an increased percentage of respiratory illnesses. Viruses that could be implicated include influenza viruses, respiratory syncytial viruses, parainfluenza viruses, coronaviruses, adenoviruses, rhinovirus and metapneumovirus. At present, little is known about the burden and effects of infections with multiple respiratory viruses. Using data acquired from the SMART study of school-children in Pittsburgh schools, viral coinfections that occurred during the 2012/2013 influenza season were examined. ILI cases in the school population were swabbed and tested for the presence of 18 different viruses. Observed coinfection cases were compared to expected cases with and without controlling for seasonality of infections. A total coinfection rate of 18.4% was found with 358 total viral infections detected in 294 children. 44 children had two viruses detected while 10 had three detected viruses. After controlling for seasonality, statistically significant coinfections were observed between FluB and RSV A, RSV B, HRV, and coronavirus OC43. Significant infections were also found between HRV and RSV A, RSV B and coronavirus OC43, adenoviruses B and C, and coronaviruses NL63 and OC43.Viral coinfections represent a significant portion of ILI cases in this population of school-children. Certain viruses appeared more frequently in coinfection than others. Future studies can help elucidate potential differences in severity or risk between mono- and coinfections.