Evaluation of Strongyloides stercoralis infection in patients with HTLV-1

Biomédica: revista del Instituto Nacional de Salud

卷:42

BernardoGalvão-Castro¹  BeatrizSoares Jacobina²  Márcia CristinaAquino Teixeira³  JoelmaNascimento de Souza³  Cíntia de LimaOliveira³  Neci Matos Soares³  WesleiAlmeida Costa Araujo³  Maria FernandaRios Grassi⁴  Marina MorenaBrito Farias⁵  Nilo ManoelPereira Vieira Barreto⁵ 

[1] Centro de HTLV, Escola Bahiana de Medicina e Saúde Pública-BAHIANA, Bahia, Brasil;

[2] Centro de HTLV, Escola Bahiana de Medicina e Saúde Pública-BAHIANA, Bahia, Brasil

[3] ;

[4] Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Bahia, Brasil;

[5] Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Bahia, Brasil;

[6] Instituto de Ciências da Saúde, Programa de Pós-graduação em Processos Interativos dos Órgãos e Sistemas, Universidade Federal da Bahia, Bahia, Brasil;

关键词: strongyloides stercoralis;    strongyloidiasis;    human t-lymphotropic virus 1;    coinfection;    helminths;   

DOI  :  10.7705/biomedica.5888

来源: DOAJ

【 摘 要 】

Introduction: Individuals infected with the human T-lymphotropic virus type 1 (HTLV-1) may present severe and disseminated forms of Strongyloides stercoralis infection with low therapeutic response.Objective: To investigate the S. stercoralis infection and the seroprevalence of IgG anti-S. stercoralis antibodies in individuals infected with HTLV-1 attending the Reference Center for HTLV-1 (CHTLV) in Salvador, Bahia, Brazil.Materials and methods: We conducted a cross-sectional study in 178 HTLV-1-infected individuals treated at the HTLV specialized center between January, 2014, and December, 2018. The parasitological diagnosis of S. stercoralis was performed using the Hoffman, Pons and Janer, agar plate culture, and Baermann-Morais methods. The IgG anti-S. stercoralis detection was performed using an in house enzyme-linked immunosorbent assay (ELISA). The HTLV-1 infection was diagnosed using a commercial ELISA and confirmed by Western blot.Results: The frequency of S. stercoralis infection was 3.4% (6/178). Individuals infected with S. stercoralis from rural areas (50.0%; 3/6) also showed S. stercoralis hyperinfection (>3,000 larvae/gram of feces). The frequency of circulating anti-S. stercoralis IgG antibodies was 20.8% (37/178).Conclusions: HTLV-1-infected people living in precarious sanitary conditions are more prone to develop severe forms of S. stercoralis infection. Considering the high susceptibility and unfavorable outcome of the infection in these individuals, the serological diagnosis for S. stercoralis should be considered when providing treatment.

【 授权许可】

Unknown