Intestinal permeability in strongyloidiasis

Brazilian Journal of Medical and Biological Research

A.l. Werneck-silva²  A.m. Sipahi²  A.o.m.c. Damião²  C.a. Buchpigue¹  K. Iriya¹  A.a. Laudanna² 

[1],Universidade de São Paulo Faculdade de Medicina Hospital das Clínicas

关键词: intestinal permeability;    51Cr-EDTA;    strongyloidiasis;    small bowel;   

DOI  :  10.1590/S0100-879X2001000300009

来源: SciELO

【 摘 要 】

The objective of the present study was to assess intestinal permeability in patients with infection caused by Strongyloides stercoralis. Twenty-six patients (16 women and 10 men), mean age 45.9, with a diagnosis of strongyloidiasis were evaluated. For comparison, 25 healthy volunteers (18 women and 7 men), mean age 44.9, without digestive disorders or intestinal parasites served as normal controls. Intestinal permeability was measured on the basis of urinary radioactivity levels during the 24 h following oral administration of chromium-labeled ethylenediaminetetraacetic acid (51Cr-EDTA) expressed as percentage of the ingested dose. The urinary excretion of 51Cr-EDTA was significantly reduced in patients with strongyloidiasis compared to controls (1.60 ± 0.74 and 3.10 ± 1.40, respectively, P = 0.0001). Intestinal permeability is diminished in strongyloidiasis. Abnormalities in mucus secretion and intestinal motility and loss of macromolecules could explain the impaired intestinal permeability.

【 授权许可】

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