Possible contribution of rare alleles of human ACE2 in the emergence of SARS-CoV-2 variants escaping the immune response

Frontiers in Immunology

Immunology

Jacques Fantini¹  Christian A. Devaux² 

[1] Institut National de la Santé et de la Recherche Médicale (INSERM) U_1072, Faculté des Sciences, Aix-Marseille Université, Marseille, France;Institut National des Sciences Biologiques (INSB), Centre National de la Recherche Scientifique (CNRS), Marseille, France;Microbes, Evolution, Phylogénie et Infections, Faculté de Pharmacie, Aix Marseille Université, Marseille, France;

关键词: SARS-CoV-2;    immune system;    selection pressure;    ACE2 receptor;    genetic drift;   

DOI  :  10.3389/fimmu.2023.1252367

 received in 2023-07-03, accepted in 2023-09-28,  发布年份 2023

来源: Frontiers

【 摘 要 】

Since the start of the SARS-CoV-2 pandemic, the rapid replacement of one lineage by another has been observed. Indeed, SARS-CoV-2 is evolving through a quasispecies mechanism leading to post-infection mutation selection under positive evolutionary pressure (host-driven viral evolution). These mutations may reduce the effectiveness of the specific neutralizing immune response against the virus. We provide here evidence that apart from the selection of SARS-CoV-2 variants by the immune system, selection by the cellular receptor can just as well select variants which escape neutralization.

【 授权许可】

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Copyright © 2023 Devaux and Fantini