Comparison of Selected Characteristics of SARS-CoV-2, SARS-CoV, and HCoV-NL63

Applied Sciences

Marianna Trebuňová¹  Marek Schnitzer¹  Darina Bačenková¹  Lucia Bednarčíková¹  Jozef Živčák¹  Tatiana Špakovská² 

[1] Department of Biomedical Engineering and Measurement, Faculty of Mechanical Engineering, Technical University of Košice, Letná 9, 04200 Košice, Slovakia;Department of Radiology, Faculty of Medicine, AGEL Hospital Košice-Šaca, Pavol Jozef Šafarik University in Košice, Lúčna 57, 04015 Košice-Šaca, Slovakia;

关键词: SARS-CoV-2;    SARS-CoV;    HCoV-NL63;    ACE2 receptor;   

DOI  :  10.3390/app11041497

来源: DOAJ

【 摘 要 】

The global pandemic known as coronavirus disease 2019 (COVID-19) was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This review article presents the taxonomy of SARS-CoV-2 coronaviruses, which have been classified as the seventh known human pathogenic coronavirus. The etiology of COVID-19 is also briefly discussed. Selected characteristics of SARS-CoV-2, SARS-CoV, and HCoV-NL63 are compared in the article. The angiotensin converting enzyme-2 (ACE-2) has been identified as the receptor for the SARS-CoV-2 viral entry. ACE2 is well-known as a counter-regulator of the renin-angiotensin system (RAAS) and plays a key role in the cardiovascular system. In the therapy of patients with COVID-19, there has been a concern about the use of RAAS inhibitors. As a result, it is hypothesized that ACE inhibitors do not directly affect ACE2 activity in clinical use. Coronaviruses are zoonotic RNA viruses. Identification of the primary causative agent of the SARS-CoV-2 is essential. Sequencing showed that the genome of the Bat CoVRaTG13 virus found in bats matches the genome of up to (96.2%) of SARS-CoV-2 virus. Sufficient knowledge of the molecular and biological mechanisms along with reliable information related to SARS-CoV-2 gives hope for a quick solution to epidemiological questions and therapeutic processes.

【 授权许可】

Unknown