Anti-inflammatory and antioxidant activity of ursolic acid: a systematic review and meta-analysis

Frontiers in Pharmacology

Pharmacology

Fengxia Wang¹  Baojiang Chen¹  Fengyang Wu¹  Xinyu Yang¹  Man Zhao¹  Yanhua Liu¹  Zhaohong Tang² 

[1] College of Animal Science and Technology, Hebei Agricultural University, Baoding, China;Hebei Research Institute of Microbiology Co., Ltd., Baoding, China;

关键词: ursolic acid;    antioxidants;    anti-inflammatory;    in vitro;    animals;    meta-analysis;   

DOI  :  10.3389/fphar.2023.1256946

 received in 2023-07-12, accepted in 2023-09-19,  发布年份 2023

来源: Frontiers

【 摘 要 】

Introduction: There is currently evidence suggesting that ursolic acid may exert a favorable influence on both anti-inflammatory and antioxidant impact. Nevertheless, the anti-inflammatory and antioxidant activities of ursolic acid have not been systematically evaluated. Consequently, this study aims to conduct a systematic review and meta-analysis regarding the impact of ursolic acid on markers of inflammatory and antioxidant activity in both animal models and in vitro systems.Methods: The search encompassed databases such as PubMed, Web of Science, Google Scholar, and ScienceDirect, up until May 2023. All eligible articles in English were included in the analysis. Standard mean difference (SMD) was pooled using a random-effects model, and the included studies underwent a thorough assessment for potential bias.Results: The final review comprised 31 articles. In disease-model related studies, animal experiments have consistently shown that ursolic acid significantly reduced the levels of inflammatory parameters IL-1β, IL-6 and TNF-α in mouse tissues. In vitro studies have similarly showed that ursolic acid significantly reduced the levels of inflammatory parameters IL-1β, IL-6, IL-8 and TNF-α. Our results showed that ursolic acid could significantly elevate SOD and GSH levels, while significantly reducing MDA levels in animal tissues. The results of in vitro studies shown that ursolic acid significantly increased the level of GSH and decreased the level of MDA.Discussion: Findings from both animal and in vitro studies suggest that ursolic acid decreases inflammatory cytokine levels, elevates antioxidant enzyme levels, and reduces oxidative stress levels (graphical abstract). This meta-analysis furnishes compelling evidence for the anti-inflammatory and antioxidant properties of ursolic acid.

【 授权许可】

Unknown   
Copyright © 2023 Zhao, Wu, Tang, Yang, Liu, Wang and Chen.