Application of optogenetic glial cells to neuron–glial communication

Frontiers in Cellular Neuroscience

Cellular Neuroscience

Kyuhwan Jung¹  Ji-Hye Park²  Sujin Hyung³ 

[1] DAWINBIO Inc., Hanam-si, Gyeonggi-do, Republic of Korea;Graduate School of Cancer Science and Policy, Cancer Biomedical Science, National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea;Precision Medicine Research Institute, Samsung Medical Center, Seoul, Republic of Korea;Division of Hematology-Oncology, Department of Medicine, Sungkyunkwan University, Samsung Medical Center, Seoul, Republic of Korea;

关键词: optogenetics;    astrocyte;    microglia;    oligodendrocyte;    Schwann cell;    neuron–glia crosstalk;   

DOI  :  10.3389/fncel.2023.1249043

 received in 2023-06-28, accepted in 2023-09-15,  发布年份 2023

来源: Frontiers

【 摘 要 】

Optogenetic techniques combine optics and genetics to enable cell-specific targeting and precise spatiotemporal control of excitable cells, and they are increasingly being employed. One of the most significant advantages of the optogenetic approach is that it allows for the modulation of nearby cells or circuits with millisecond precision, enabling researchers to gain a better understanding of the complex nervous system. Furthermore, optogenetic neuron activation permits the regulation of information processing in the brain, including synaptic activity and transmission, and also promotes nerve structure development. However, the optimal conditions remain unclear, and further research is required to identify the types of cells that can most effectively and precisely control nerve function. Recent studies have described optogenetic glial manipulation for coordinating the reciprocal communication between neurons and glia. Optogenetically stimulated glial cells can modulate information processing in the central nervous system and provide structural support for nerve fibers in the peripheral nervous system. These advances promote the effective use of optogenetics, although further experiments are needed. This review describes the critical role of glial cells in the nervous system and reviews the optogenetic applications of several types of glial cells, as well as their significance in neuron–glia interactions. Together, it briefly discusses the therapeutic potential and feasibility of optogenetics.

【 授权许可】

Unknown   
Copyright © 2023 Hyung, Park and Jung.