Hyperlipidemia in immune thrombocytopenia: a retrospective study

Thrombosis Journal

Research

Hui Lu¹  Liang Wang²  Fangmiao Jing³  Ming Hou⁴  Yafei Yu⁵  Xinguang Liu⁵  Yajing Zhao⁵  Shouqing Han⁵ 

[1] Affiliated Hospital of Weifang Medical University, Weifang, Shandong, China;Affiliated Hospital of Weifang Medical University, Weifang, Shandong, China;Department of Hematology, Shengli Oilfield Central Hospital, Dongying, China;Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China;Department of Hematology, Qilu Hospital of Shandong University, 107 West Wenhua Road, 250012, Jinan, Shandong, China;Leading Research Group of Scientific Innovation, Department of Science and Technology of Shandong Province, Qilu Hospital of Shandong University, Jinan, China;Department of Hematology, Qilu Hospital of Shandong University, 107 West Wenhua Road, 250012, Jinan, Shandong, China;Shandong Provincial Key Laboratory of Immunohematology, Qilu Hospital of Shandong University, Jinan, China;

关键词: Immune thrombocytopenia;    Bleeding;    Lipid metabolism;    Statins;   

DOI  :  10.1186/s12959-023-00545-9

 received in 2023-04-22, accepted in 2023-09-13,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundImmune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease characterized by low platelet count and bleeding manifestations. However, some patients also suffered from atherosclerosis or even infarction. Apart from activated platelets, lipid metabolism takes a large part in the formation of atherosclerosis and metabolic syndrome. The lipid metabolic state in ITP patients is still unknown.MethodsWe retrospectively reviewed 302 hospitalized ITP patients in our cohort, comparing their blood lipids, bleeding symptoms, metabolic diseases and treatment responses.ResultsWe found a high proportion of ITP patients suffered from hyperlipidemia, and other metabolic diseases including cardiovascular or cerebral atherosclerosis or infarction, hypertension, and type 2 diabetes. Hyperlipidemia was associated with severe bleeding and treatment refractoriness in ITP. Statins could alleviate thrombocytopenia and bleeding severity, and facilitate ITP treatment, while improving hyperlipidemia in ITP patients.ConclusionsOur present study demonstrated that lipid metabolism might play an indispensable role in ITP pathogenesis and development.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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Fig. 1