Etiological relationship between lipid metabolism and endometrial carcinoma

Lipids in Health and Disease

Review

Hongyan Wu¹  Wenzhe Li¹  Yi Xu¹  Ya Wang²  Xinling Zeng³  Cunjian Yi⁴  Jie Tan⁵  Maokun Li⁶ 

[1] Department of Endocrinology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China;Department of Endocrinology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China;Department of Hubei Provincial Clinical Research Center for Personalized Diagnosis and Treatment of Cancer, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China;Department of Gynecology and Obstetrics, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China;Department of Gynecology and Obstetrics, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China;Department of Hubei Provincial Clinical Research Center for Personalized Diagnosis and Treatment of Cancer, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China;Department of Hematology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China;Department of Hubei Provincial Clinical Research Center for Personalized Diagnosis and Treatment of Cancer, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China;

关键词: Lipid metabolism;    Endometrial carcinoma;    Etiological relationship;    Statins;    Biological mechanisms;   

DOI  :  10.1186/s12944-023-01868-2

 received in 2023-02-15, accepted in 2023-07-05,  发布年份 2023

来源: Springer

【 摘 要 】

Endometrial carcinoma (EC) has become one of the most common gynecological malignant neoplasms in developed countries worldwide. Studies have shown that this may be closely related to the abnormal metabolism of blood lipids, which was the most significant metabolic change in the human body in this cancer. In this review, we focus on the correlation between lipid metabolism and EC and discuss the evidence that abnormal lipid metabolism promotes an increase in EC growth and metabolism, as well as the regulatory mechanism and related signaling pathways involved in this relationship. In addition, we also discussed the research progress of targeted therapies and drug treatments for EC that act on lipid metabolism, and statins are expected to become adjuvant drugs for EC in the future. This review will provide a systematic view for a better understanding of the etiological relationship between lipid metabolism and EC and further open up new therapeutic possibilities and effective treatments for EC by targeting lipid metabolism.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

Fig. 1