Cardiac and renal function in a large cohort of amateur marathon runners

Cardiovascular Ultrasound

Research

Wasiem Sanad¹  Sebastian Spethmann¹  Gert Baumann¹  Fabian Knebel¹  Henryk Dreger¹  Bernd Hewing¹  Sabrina Schroeckh¹  Ingolf Schimke²  Adrian C Borges³  Sebastian Schattke³  Fabian Halleck⁴  Harm Peters⁴  Jürgen Lock⁵  Lars Brechtel⁵ 

[1] Department of Cardiology and Angiology, Charité-Universitätsmedizin Berlin, Campus Mitte, Charitéplatz 1, 10117, Berlin, Germany;Department of Medical Chemistry und Pathochemistry, Charité-Universitätsmedizin Berlin, Berlin, Germany;Department of Medicine I, Cardiology, Helios Klinikum Emil von Behring, Berlin, Germany;Department of Nephrology, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany;SMS Medical Institute, Berlin, Germany;Berlin Academy for Sport Medicine, Berlin, Germany;SCC Running Events GmbH, Berlin, Germany;

关键词: Athlete’s heart;    Endurance exercise;    Natriuretic peptides;    Diastolic function;    Renal function;   

DOI  :  10.1186/s12947-015-0007-6

 received in 2015-01-24, accepted in 2015-03-09,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundParticipation of amateur runners in endurance races continues to increase. Previous studies of marathon runners have raised concerns about exercise-induced myocardial and renal dysfunction and damage. In our pooled analysis, we aimed to characterize changes of cardiac and renal function after marathon running in a large cohort of mostly elderly amateur marathon runners.MethodsA total of 167 participants of the BERLIN-MARATHON (female n = 89, male n = 78; age = 50.3 ± 11.4 years) were included and cardiac and renal function was analyzed prior to, immediately after and 2 weeks following the race by echocardiography and blood tests (including cardiac troponin T, NT-proBNP and cystatin C).ResultsAmong the runners, 58% exhibited a significant increase in cardiac biomarkers after completion of the marathon. Overall, the changes in echocardiographic parameters for systolic or diastolic left and right ventricular function did not indicate relevant myocardial dysfunction. Notably, 30% of all participants showed >25% decrease in cystatin C-estimated glomerular filtration rate (GFR) from baseline directly after the marathon; in 8%, we observed a decline of more than 50%. All cardiac and renal parameters returned to baseline ranges within 2 weeks after the marathon.ConclusionsThe increase in cardiac biomarkers after completing a marathon was not accompanied by relevant cardiac dysfunction as assessed by echocardiography. After the race, a high proportion of runners experienced a decrease in cystatin C-estimated GFR, which is suggestive of transient, exercise-related alteration of renal function. However, we did not observe persistent detrimental effects on renal function.

【 授权许可】

Unknown   
© Hewing et al.; licensee BioMed Central. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.