Upregulation of circulating IL-15 by treadmill running in healthy individuals: Is IL-15 an endocrine mediator of the beneficial effects of endurance exercise?

Endocrine Journal

Tomomi Kantani⁴  Keiichi Watanabe²  Yoshiaki Tamura³  Masao Kaneki³  Junichi Hayashi¹  Nobuhiko Ishida² 

[1] Department of General Medicine, Kyorin University School of Medicine, Mitaka, Japan;Wafukai Medical Corporation Tama Rehabilitation Academy, Ome, Japan;Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Shriners Hospitals for Children, Harvard Medical School, Charlestown, USA;Wafukai Tama Rehabilitation Hospital, Ome, Japan

关键词: IL-15;    Myokine;    Endurance exercise;    Treadmill;   

DOI  :  10.1507/endocrj.K10E-400

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(18)Cited-By(19)The beneficial effects of endurance exercise include insulin-sensitization and reduction of fat mass.Limited knowledge is available about the mechanisms by which endurance exercise exerts the salutary effects.Myokines, cytokines secreted by skeletal muscle, have been recognized as a potential mediator.Recently, a role of skeletal muscle-derived interleukin-15 (IL-15) in improvement of fat-lean body mass composition and insulin sensitivity has been proposed.Yet, previous studies have reported that endurance training does not increase production or secretion of IL-15 in skeletal muscle.Here, we show that in opposition to previous findings, 30-min treadmill running at 70% of age-predicted maximum heart rate resulted in a significant increase in circulating IL-15 level in untrained healthy young men.These findings suggest that IL-15 might play a role in the systemic anti-obesogenic and insulin-sensitizing effects of endurance exercise, not only as a paracrine and autocrine but also as an endocrine factor.

【 授权许可】

Unknown