Dietary saturated and monounsaturated fats protect against acute acetaminophen hepatotoxicity by altering fatty acid composition of liver microsomal membrane in rats

Lipids in Health and Disease

Research

Hye Jin Hwang¹  Haeyon Chung²  Soo Yeon Kim²  Jinah Hwang³  Yun-Hee Chang³  Eugene Shim⁴  Jung Hwa Park⁵ 

[1] Department of Food and Nutrition, College of Human Ecology, Dongeui University, 614-714, Busan, Republic of Korea;Department of Food and Nutrition, Division of Natural Sciences, 100-751, Seoul, Republic of Korea;Department of Foods and Nutrition, College of Natural Sciences, Myongji University, 449-728, YongIn, Republic of Korea;National Hypertension Center, Yonsei University Health System, 120-752, Seoul, Republic of Korea;Research Institute of Food & Nutritional Sciences, Yonsei University, 120-749, Seoul, Republic of Korea;

关键词: Phospholipid fatty acid composition;    SFA;    MUFA;    Hepatotoxicity;    Cytochrome P-450 2E1;   

DOI  :  10.1186/1476-511X-10-184

 received in 2011-06-24, accepted in 2011-10-20,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundDietary polyunsaturated fats increase liver injury in response to ethanol feeding. We evaluated the effect of dietary corn oil (CO), olive oil (OO), and beef tallow (BT) on fatty acid composition of liver microsomal membrane and acute acetaminophen hepatotoxicity.MethodsMale Sprague-Dawley rats were fed 15% (wt/wt) CO, OO or BT for 6 weeks. After treatment with acetaminophen (600 mg/kg), samples of plasma and liver were taken for analyses of the fatty acid composition and toxicity.ResultsTreatment with acetaminophen significantly elevated levels of plasma GOT and GPT as well as hepatic TBARS but reduced hepatic GSH levels in CO compared to OO and BT groups. Acetaminophen significantly induced protein expression of cytochrome P450 2E1 in the CO group. In comparison with the CO diet, lower levels of linoleic acid, higher levels of oleic acids and therefore much lower ratios of linoleic to oleic acid were detected in rats fed OO and BT diets.ConclusionsDietary OO and BT produces similar liver microsomal fatty acid composition and may account for less severe liver injury after acetaminophen treatment compared to animals fed diets with CO rich in linoleic acid. These findings imply that types of dietary fat may be important in the nutritional management of drug-induced hepatotoxicity.

【 授权许可】

CC BY   
© Hwang et al; licensee BioMed Central Ltd. 2011