Lipoprotein subclass profiles in young adults born preterm at very low birth weight

Lipids in Health and Disease

Short Report

Sture Andersson¹  Anna-Liisa Järvenpää¹  Antti J Kangas²  Petteri Hovi³  Karoliina Wehkalampi³  Eero Kajantie³  Johan G Eriksson⁴  Pasi Soininen⁵  Mika Ala-Korpela⁶ 

[1] Children’s Hospital Helsinki University Central Hospital and University of Helsinki, Stenbäckinkatu 11, FI-00029, HUS Helsinki, Finland;Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, P.O.Box 5000, Aapistie 5 A, 90014, Oulu, Finland;Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, Mannerheimintie 166, FI-00271, Helsinki, Finland;Children’s Hospital Helsinki University Central Hospital and University of Helsinki, Stenbäckinkatu 11, FI-00029, HUS Helsinki, Finland;Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, Mannerheimintie 166, FI-00271, Helsinki, Finland;Unit of General Practice Helsinki University Central Hospital and University of Helsinki, P.O. Box 20, FI-00029, HUS Helsinki, Finland;Folkhälsan Research Center University of Helsinki, Haartmaninkatu 8, FI-00014, Helsinki, Finland;Department of General Practice and Primary Health Care, University of Helsinki, Haartmaninkatu 8, FI-00014, Helsinki, Finland;NMR Metabolomics Laboratory, School of Pharmacy University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland;NMR Metabolomics Laboratory, School of Pharmacy University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland;Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, P.O.Box 5000, Aapistie 5 A, 90014, Oulu, Finland;Computational Medicine, School of Social and Community Medicine University of Bristol, Oakfield House, Oakfield Grove, BS8 2BN, Bristol, UK;

关键词: Very low birth weight;    Prematurity;    Lipoprotein;    Lipids;    Subclass;   

DOI  :  10.1186/1476-511X-12-57

 received in 2013-01-29, accepted in 2013-04-24,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundAdults born preterm at very low birth weight (VLBW ≤ 1500g) have increased risk factors for cardiovascular diseases including high blood pressure and impaired glucose regulation. Non-optimal lipoprotein profile is generally also likely to affect the increased cardiovascular risk, but lipoprotein subclass level data on adults born at VLBW are sparse.Subjects and methodsWe studied 162 subjects born at VLBW and 169 term-born controls, aged 19 to 27 years. Total lipid, triglyceride and cholesterol concentrations of 14 lipoprotein subclasses were determined by proton nuclear magnetic resonance spectroscopy in the fasting state and in 2-hour serum samples from an oral glucose tolerance test.FindingsIn comparison to controls, VLBW subjects had significantly higher fasting concentration of triglycerides in chylomicrons and largest very-low-density lipoprotein particles [XXL-VLDL-TG, difference 0.026 (95% CI: 0.004 to 0.049), P = 0.024], and of triglycerides in small high-density lipoprotein particles [S-HDL-TG, 0.026 (95% CI: 0.002 to 0.051), P = 0.037]. The seemingly important role of triglycerides was further supported by principal component analysis in which the first component was characterized by multiple lipoprotein triglyceride measures.ConclusionsYoung adults born at VLBW and their peers born at term had triglyceride-related differences in both VLDL and HDL subclasses. These differences suggest that the increased risk factors for cardiovascular diseases among the VLBW individuals in adulthood may partly relate to impaired triglyceride metabolism.

【 授权许可】

Unknown   
© Hovi et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.