Lipoprotein subclass profiles in young adults born preterm at very low birth weight

Lipids in Health and Disease

Karoliina Wehkalampi⁴  Mika Ala-Korpela⁵  Johan G Eriksson³  Sture Andersson⁴  Anna-Liisa Järvenpää⁴  Antti J Kangas²  Pasi Soininen¹  Eero Kajantie⁴  Petteri Hovi⁴ 

[1] NMR Metabolomics Laboratory, School of Pharmacy University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland;Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Aapistie 5 A, P.O.Box 5000, 90014 Oulu, Finland;Department of General Practice and Primary Health Care, University of Helsinki, Haartmaninkatu 8, FI-00014 Helsinki, Finland;Children’s Hospital Helsinki University Central Hospital and University of Helsinki, Stenbäckinkatu 11, FI-00029 HUS Helsinki, Finland;Computational Medicine, School of Social and Community Medicine University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK

关键词: Subclass;    Lipids;    Lipoprotein;    Prematurity;    Very low birth weight;   

Others  :  834749
DOI  :  10.1186/1476-511X-12-57

 received in 2013-01-29, accepted in 2013-04-24,  发布年份 2013

【 摘 要 】

Background

Adults born preterm at very low birth weight (VLBW ≤ 1500g) have increased risk factors for cardiovascular diseases including high blood pressure and impaired glucose regulation. Non-optimal lipoprotein profile is generally also likely to affect the increased cardiovascular risk, but lipoprotein subclass level data on adults born at VLBW are sparse.

Subjects and methods

We studied 162 subjects born at VLBW and 169 term-born controls, aged 19 to 27 years. Total lipid, triglyceride and cholesterol concentrations of 14 lipoprotein subclasses were determined by proton nuclear magnetic resonance spectroscopy in the fasting state and in 2-hour serum samples from an oral glucose tolerance test.

Findings

In comparison to controls, VLBW subjects had significantly higher fasting concentration of triglycerides in chylomicrons and largest very-low-density lipoprotein particles [XXL-VLDL-TG, difference 0.026 (95% CI: 0.004 to 0.049), P = 0.024], and of triglycerides in small high-density lipoprotein particles [S-HDL-TG, 0.026 (95% CI: 0.002 to 0.051), P = 0.037]. The seemingly important role of triglycerides was further supported by principal component analysis in which the first component was characterized by multiple lipoprotein triglyceride measures.

Conclusions

Young adults born at VLBW and their peers born at term had triglyceride-related differences in both VLDL and HDL subclasses. These differences suggest that the increased risk factors for cardiovascular diseases among the VLBW individuals in adulthood may partly relate to impaired triglyceride metabolism.

【 授权许可】

   
2013 Hovi et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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