Brachial artery endothelial function is stable across the morning in young men

Cardiovascular Ultrasound

Research

Janet P. Wallace¹  Chad C. Wiggins¹  Saurabh S. Thosar²  Steven A. Shea³ 

[1] Department of Kinesiology, School of Public Health, Indiana University Bloomington, 47405, Bloomington, Indiana, USA;Oregon Institute of Occupational Health Sciences, Oregon Health and Science University, L 606/RJH 1553 A, 97139, Portland, Oregon, USA;Oregon Institute of Occupational Health Sciences, Oregon Health and Science University, L 606/RJH 1553 A, 97139, Portland, Oregon, USA;Department of Public Health and Preventive Medicine, Oregon Health & Science University, 97239, Portland, Oregon, USA;

关键词: Morning cardiovascular vulnerability;    Adverse cardiac events;    Flow mediated dilation;    Endothelial function;    Sleep inertia;   

DOI  :  10.1186/s12947-015-0036-1

 received in 2015-08-21, accepted in 2015-09-22,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundThe morning hours are associated with increased cardiovascular (CV) risk, and vascular endothelial function (VEF) is a strong predictor of CV disease. A diurnal rhythm in VEF has been established but the morning variation in VEF is not well-documented. Thus, we tested if VEF is impaired across the vulnerable morning period.MethodsAfter overnight fasts, eight healthy men (age 26.3 ± 3 yr) underwent assessments of VEF under standardized testing conditions every 2 h from 0700 to 1300 h on two separate days. VEF was estimated following 5 min brachial artery occlusions by hyperemic flow-mediated dilation (FMD).ResultsThere was no significant change in FMD or hyperemic shear stimulus across the 6 h vulnerable period on either day, despite changes in physical activity and meals across these periods.ConclusionIn this healthy group of young men, VEF is stable across the vulnerable morning period when typical behaviors occurred (breakfast and physical activity). Future research should focus on the roles of sleep, physical inactivity during sleep and endogenous circadian rhythm in VEF.

【 授权许可】

CC BY   
© Thosar et al. 2015