The effects of folic acid supplementation on endothelial function in adults: a systematic review and dose-response meta-analysis of randomized controlled trials

Nutrition Journal

Review

Cain C. T. Clark¹  Mohammad Zamani²  Saeede Saadati³  Elnaz Golalipour⁴  Mohsen Yousefi⁴  Kaveh Naseri⁵  Fatemeh Rezaiian⁶  Damoon Ashtary-Larky⁷  Omid Asbaghi⁸  Samira Rastgoo⁹ 

[1] Centre for Intelligent Healthcare, Coventry University, CV1 5FB, Coventry, UK;Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran;Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, Australia;Faculty of Medicine, Shahid Beheshti University of Medical sciences, Tehran, Iran;Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran;National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Department of Cellular and Molecular Nutrition, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Science and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran;

关键词: Endothelial function;    Flow mediated dilation;    FMD;    Folic acid supplementation;    Meta-analysis;   

DOI  :  10.1186/s12937-023-00843-y

 received in 2022-11-09, accepted in 2023-02-16,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundEndothelial dysfunction serves as an early marker for the risk of cardiovascular disease (CVD); therefore, it is an attractive site of therapeutic interventions to reduce the risk of CVD. This study was conducted to investigate the effect of folic acid supplementation on endothelial function markers in randomized controlled trials (RCTs).MethodsPubMed, ISI web of science, and Scopus databases were searched up to July 2022 for detecting eligible studies. A random-effects model was used for meta-analysis, and linear Meta-regression and non-linear dose-response analysis were performed to assess whether the effect of folic acid supplementation was affected by the dose and duration of intervention. Cochrane tools were also used to assess the risk of bias in the included studies.ResultsTwenty-one studies, including 2025 participants (1010 cases and 1015 controls), were included in the present meta-analysis. Folic acid supplementation significantly affected the percentage of flow-mediated dilation (FMD%) (WMD: 2.59%; 95% CI: 1.51, 3.67; P < 0.001) and flow-mediated dilation (FMD) (WMD: 24.38 μm; 95% CI: 3.08, 45.68; P = 0.025), but not end-diastolic diameter (EDD) (WMD: 0.21 mm; 95% CI: − 0.09, 0.52; P = 0.176), and intercellular adhesion molecule (ICAM) (WMD: 0.18 ng/ml; 95% CI: − 10.02, 13.81; P = 0.755).ConclusionsThese findings suggest that folic acid supplementation may improve endothelial function by increasing FMD and FMD% levels.Trial registrationPROSPERO registration cod: CRD42021289744.

【 授权许可】

CC BY   
© The Author(s) 2023

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