Peripheral vascular dysfunction in migraine: a review

The Journal of Headache and Pain

Review Article

Davide Grassi¹  Simona Sacco²  Raffaele Ornello²  Antonio Carolei²  Patrizia Ripa²  Francesca Pistoia²  Tobias Kurth³ 

[1] Department of Life, Health, and Eviromental Sciences, University of L’Aquila, 67100, L’Aquila, Italy;Department of Neurology and Regional Headache Center, University of L’Aquila, Piazzale Salvatore Tommasi 1, 67100, L’Aquila, Italy;Inserm Research Center for Epidemiology and Biostatistics, Team Neuroepidemiology, F-33000, Bordeaux, France;University of Bordeaux, F-33000, Bordeaux, France;

关键词: Migraine;    Migraine with aura;    Arterial stiffness;    Endothelial function;    Flow mediated dilation;    Pulse wave velocity;    Augmentation index;    Stroke;    Coronary artery disease;    Cardiovascular disease;    Risk factors;   

DOI  :  10.1186/1129-2377-14-80

 received in 2013-08-05, accepted in 2013-09-20,  发布年份 2013

来源: Springer

【 摘 要 】

Numerous studies have indicated an increased risk of vascular disease among migraineurs. Alterations in endothelial and arterial function, which predispose to atherosclerosis and cardiovascular diseases, have been suggested as an important link between migraine and vascular disease. However, the available evidence is inconsistent. We aimed to review and summarize the published evidence about the peripheral vascular dysfunction of migraineurs.We systematically searched in BIOSIS, the Cochrane database, Embase, Google scholar, ISI Web of Science, and Medline to identify articles, published up to April 2013, evaluating the endothelial and arterial function of migraineurs.Several lines of evidence for vascular dysfunction were reported in migraineurs. Findings regarding endothelial function are particularly controversial since studies variously indicated the presence of endothelial dysfunction in migraineurs, the absence of any difference in endothelial function between migraineurs and non-migraineurs, and even an enhanced endothelial function in migraineurs. Reports on arterial function are more consistent and suggest that functional properties of large arteries are altered in migraineurs.Peripheral vascular function, particularly arterial function, is a promising non-invasive indicator of the vascular health of subjects with migraine. However, further targeted research is needed to understand whether altered arterial function explains the increased risk of vascular disease among patients with migraine.

【 授权许可】

CC BY   
© Sacco et al.; licensee Springer. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.