Neoadjuvant chemotherapy for stage II–III breast cancer: a single-center experience

World Journal of Surgical Oncology

Research

Mohamed Abozeid¹  Haidi Abd El Zaher²  Hamada Fathy²  Mohammed Faisal³ 

[1] Department of Oncology and Nuclear Medicine, Faculty of Medicine, Suez Canal University, Ismailia, Egypt;Surgical Oncology Unit, Department of Surgery, Faculty of Medicine, Suez Canal University Hospital, Ismailia, Egypt;Surgical Oncology Unit, Department of Surgery, Faculty of Medicine, Suez Canal University Hospital, Ismailia, Egypt;Department of General Surgery, Torsby Hospital, Region Värmland County Council, Värmland, Sweden;

关键词: Neoadjuvant chemotherapy;    Breast-conserving surgery;    Breast cancer;    Mastectomy;   

DOI  :  10.1186/s12957-023-03199-z

 received in 2022-10-07, accepted in 2023-09-19,  发布年份 2023

来源: Springer

【 摘 要 】

IntroductionWe conducted this study to reflect a single-center experience with the use of neoadjuvant systemic chemotherapy (NAC) for the management of women with operable breast cancer.MethodsWe conducted a retrospective chart review on all women presenting with operable, stage II–III, breast cancer and were scheduled for NAC at Suez Canal University Hospital. The primary outcome of this study was to estimate the proportion of patients with breast cancer who become eligible for breast-conserving surgery (BCS) after (NAC).ResultsA total of 147 patients were included. Before the initiation of chemotherapy, only 66 (44.9%) patients were indicated for (BCS). A total of 40 (49.4%) new patients, out of the 81 patients who were ineligible before chemotherapy, became eligible for BCS after NAC (95% CI 39.3–61.9%). On the other hand, 8 (12.1%) patients became ineligible for BCS after NAC, out of 66 patients who were initially eligible. Out of the 98 eligible patients for BCS after chemotherapy, 72 (73.5%) patients underwent the surgery, and the remaining 26 (26.5%) patients chose modified radical mastectomy (MRM). A total of 55 out of 72 (76.4%) patients achieved pathological complete response (pCR). One woman (0.1%) experienced relapse in the 3rd year of follow-up and three women (2%) experienced relapse in the 5th year of follow-up. We found a statistically significant relationship between patients who became eligible for breast-conserving surgery and both age and estrogen receptor negativity (p = 0.001 and 0.007, respectively).ConclusionNAC can play a crucial role in increasing the rate of eligibility for BCS among women with operable, stage II–III, breast cancer.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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