Evaluation of 3D multi-contrast joint intra- and extracranial vessel wall cardiovascular magnetic resonance

Journal of Cardiovascular Magnetic Resonance

Research

Le He¹  Xihai Zhao¹  Zechen Zhou¹  Rui Li¹  Chun Yuan²  Xiaole Wang³  Niranjan Balu⁴  Jinnan Wang⁵ 

[1]Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China

[2]Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China

[3]Department of Radiology, University of Washington, Seattle, WA, USA

[4]Department of Biomedical Engineering, Tsinghua University, Beijing, China

[5]Department of Radiology, University of Washington, Seattle, WA, USA

[6]Department of Radiology, University of Washington, Seattle, WA, USA

[7]Philips Research North America, Briarcliff Manor, NY, USA

关键词: Atherosclerosis;    Vessel wall imaging;    Carotid artery;    Intracranial artery;    3D-MERGE;    SNAP;    VISTA;    Magnetic resonance;   

DOI  :  10.1186/s12968-015-0143-z

 received in 2014-10-15, accepted in 2015-05-01,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundMulti-contrast vessel wall cardiovascular magnetic resonance (CMR) has demonstrated its capability for atherosclerotic plaque morphology measurement and component characterization in different vasculatures. However, limited coverage and partial volume effect with conventional two-dimensional (2D) techniques might cause lesion underestimation. The aim of this work is to evaluate the performance in a) blood suppression and b) vessel wall delineation of three-dimensional (3D) multi-contrast joint intra- and extracranial vessel wall imaging at 3T.MethodsThree multi-contrast 3D black blood (BB) sequences with T1, T2 and heavy T1 weighting and a custom designed 36-channel neurovascular coil covering the entire intra- and extracranial vasculature have been used and investigated in this study. Two healthy subjects were recruited for sequence parameter optimization and twenty-five patients were consecutively scanned for image quality and blood suppression assessment. Qualitative image scores of vessel wall delineation as well as quantitative Signal-to-Noise Ratio (SNR) and Contrast-to-Noise Ratio (CNR) were evaluated at five typical locations ranging from common carotid arteries to middle cerebral arteries.ResultsThe 3D multi-contrast images acquired within 15mins allowed the vessel wall visualization with 0.8 mm isotropic spatial resolution covering intra- and extracranial segments. Quantitative wall and lumen SNR measurements for each sequence showed effective blood suppression at all selected locations (P < 0.0001). Although the wall-lumen CNR varied across measured locations, each sequence provided good or adequate image quality in both intra- and extracranial segments.ConclusionsThe proposed 3D multi-contrast vessel wall technique provides isotropic resolution and time efficient solution for joint intra- and extracranial vessel wall CMR.

【 授权许可】

Unknown   
© Zhou et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.