Simultaneous three-dimensional myocardial T1 and T2 mapping in one breath hold with 3D-QALAS

Journal of Cardiovascular Magnetic Resonance

Research

Sofia Kvernby¹  Henrik Haraldsson¹  Carl-Johan Carlhäll²  Jan Engvall²  Tino Ebbers³  Marcel Jan Bertus Warntjes⁴ 

[1] Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden;Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden;Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden;Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden;Department of Clinical Physiology, County Council of Östergötland, Linköping, Sweden;Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden;Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden;Division of Media and Information Technology, Department of Science and Technology, Linköping University, Linköping, Sweden;Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden;Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden;SyntheticMR AB, Linköping, Sweden;

关键词: Relaxation time;    T1 mapping;    T2 mapping;    Three-dimensional;    Myocardium;    Cardiovascular magnetic resonance;   

DOI  :  10.1186/s12968-014-0102-0

 received in 2014-02-27, accepted in 2014-11-21,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundQuantification of the longitudinal- and transverse relaxation time in the myocardium has shown to provide important information in cardiac diagnostics. Methods for cardiac relaxation time mapping generally demand a long breath hold to measure either T1 or T2 in a single 2D slice. In this paper we present and evaluate a novel method for 3D interleaved T1 and T2 mapping of the whole left ventricular myocardium within a single breath hold of 15 heartbeats.MethodsThe 3D-QALAS (3D-quantification using an interleaved Look-Locker acquisition sequence with T2 preparation pulse) is based on a 3D spoiled Turbo Field Echo sequence using inversion recovery with interleaved T2 preparation. Quantification of both T1 and T2 in a volume of 13 slices with a resolution of 2.0x2.0x6.0 mm is obtained from five measurements by using simulations of the longitudinal magnetizations Mz. This acquisition scheme is repeated three times to sample k-space. The method was evaluated both in-vitro (validated against Inversion Recovery and Multi Echo) and in-vivo (validated against MOLLI and Dual Echo).ResultsIn-vitro, a strong relation was found between 3D-QALAS and Inversion Recovery (R = 0.998; N = 10; p < 0.01) and between 3D-QALAS and Multi Echo (R = 0.996; N = 10; p < 0.01). The 3D-QALAS method showed no dependence on e.g. heart rate in the interval of 40–120 bpm. In healthy myocardium, the mean T1 value was 1083 ± 43 ms (mean ± SD) for 3D-QALAS and 1089 ± 54 ms for MOLLI, while the mean T2 value was 50.4 ± 3.6 ms 3D-QALAS and 50.3 ± 3.5 ms for Dual Echo. No significant difference in in-vivo relaxation times was found between 3D-QALAS and MOLLI (N = 10; p = 0.65) respectively 3D-QALAS and Dual Echo (N = 10; p = 0.925) for the ten healthy volunteers.ConclusionsThe 3D-QALAS method has demonstrated good accuracy and intra-scan variability both in-vitro and in-vivo. It allows rapid acquisition and provides quantitative information of both T1 and T2 relaxation times in the same scan with full coverage of the left ventricle, enabling clinical application in a broader spectrum of cardiac disorders.

【 授权许可】

CC BY   
© Kvernby et al.; licensee BioMed Central Ltd. 2014