Journal of Cardiovascular Magnetic Resonance | |
T1 mapping and T2 mapping at 3T for quantifying the area-at-risk in reperfused STEMI patients | |
Research | |
Steven K. White1  Heerajnarain Bulluck1  Derek J. Hausenloy2  Anna Herrey3  Marianna Fontana3  Amna Abdel-Gadir3  Stefania Rosmini3  Thomas A. Treibel3  Charlotte Manisty3  Anish Bhuva3  James C. Moon4  Ashley Groves5  Leon Menezes5  Simon M. Y. Wan5  | |
[1] The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, WC1E 6HX, London, UK;The National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, UK;The Heart Hospital, University College London Hospital, London, UK;The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, WC1E 6HX, London, UK;The National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, UK;The Heart Hospital, University College London Hospital, London, UK;Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore, Singapore;National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore;The Heart Hospital, University College London Hospital, London, UK;The National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, UK;The Heart Hospital, University College London Hospital, London, UK;UCL Institute of Nuclear Medicine, University College London Hospital, London, UK; | |
关键词: Area-at-risk; Myocardial salvage; Cardiovascular MR; T1 mapping; T2 mapping; ST-elevation myocardial infarction; Primary percutaneous intervention; | |
DOI : 10.1186/s12968-015-0173-6 | |
received in 2015-04-14, accepted in 2015-07-16, 发布年份 2015 | |
来源: Springer | |
【 摘 要 】
BackgroundWhether T1-mapping cardiovascular magnetic resonance (CMR) can accurately quantify the area-at-risk (AAR) as delineated by T2 mapping and assess myocardial salvage at 3T in reperfused ST-segment elevation myocardial infarction (STEMI) patients is not known and was investigated in this study.Methods18 STEMI patients underwent CMR at 3T (Siemens Bio-graph mMR) at a median of 5 (4–6) days post primary percutaneous coronary intervention using native T1 (MOLLI) and T2 mapping (WIP #699; Siemens Healthcare, UK). Matching short-axis T1 and T2 maps covering the entire left ventricle (LV) were assessed by two independent observers using manual, Otsu and 2 standard deviation thresholds. Inter- and intra-observer variability, correlation and agreement between the T1 and T2 mapping techniques on a per-slice and per patient basis were assessed.ResultsA total of 125 matching T1 and T2 mapping short-axis slices were available for analysis from 18 patients. The acquisition times were identical for the T1 maps and T2 maps. 18 slices were excluded due to suboptimal image quality. Both mapping sequences were equally prone to susceptibility artifacts in the lateral wall and were equally likely to be affected by microvascular obstruction requiring manual correction. The Otsu thresholding technique performed best in terms of inter- and intra-observer variability for both T1 and T2 mapping CMR. The mean myocardial infarct size was 18.8 ± 9.4 % of the LV. There was no difference in either the mean AAR (32.3 ± 11.5 % of the LV versus 31.6 ± 11.2 % of the LV, P = 0.25) or myocardial salvage index (0.40 ± 0.26 versus 0.39 ± 0.27, P = 0.20) between the T1 and T2 mapping techniques. On a per-slice analysis, there was an excellent correlation between T1 mapping and T2 mapping in the quantification of the AAR with an R2 of 0.95 (P < 0.001), with no bias (mean ± 2SD: bias 0.0 ± 9.6 %). On a per-patient analysis, the correlation and agreement remained excellent with no bias (R2 0.95, P < 0.0001, bias 0.7 ± 5.1 %).ConclusionsT1 mapping CMR at 3T performed as well as T2 mapping in quantifying the AAR and assessing myocardial salvage in reperfused STEMI patients, thereby providing an alternative CMR measure of the the AAR.
【 授权许可】
CC BY
© Bulluck et al. 2015
【 预 览 】
Files | Size | Format | View |
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RO202311104897351ZK.pdf | 1664KB | download |
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