Current use of autologous adipose tissue-derived stromal vascular fraction cells for orthopedic applications

Journal of Biomedical Science

Review

Lin-Woo Kang¹  Kwang Seung Park²  Sang Hee Lee²  Moonhee Park³  Jung Hun Lee⁴  Jaewoo Pak⁵ 

[1] Department of Biological Sciences, Konkuk University, 1 Hwayangdong, Gwangjingu, 05029, Seoul, Republic of Korea;National Leading Research Laboratory, Department of Biological Sciences, Myongji University, 116 Myongjiro, 17058, Yongin, Gyeonggido, Republic of Korea;National Leading Research Laboratory, Department of Biological Sciences, Myongji University, 116 Myongjiro, 17058, Yongin, Gyeonggido, Republic of Korea;DNA Analysis Division, Seoul institute, National Forensic Service, 139 Jiyangro, Yangcheongu, 08036, Seoul, Republic of Korea;Stems Medical Clinic, 32-3 Chungdamdong, Gangnamgu, 06068, Seoul, Republic of Korea;National Leading Research Laboratory, Department of Biological Sciences, Myongji University, 116 Myongjiro, 17058, Yongin, Gyeonggido, Republic of Korea;Stems Medical Clinic, 32-3 Chungdamdong, Gangnamgu, 06068, Seoul, Republic of Korea;TEDA-Puhua International Hospital, 300457, Tianjin, People’s Republic of China;Life Science Institute, Komplek Permata Senayan, Jalan Tentara Pelajar, 12210, Jakarta Selatan, Indonesia;

关键词: Mesenchymal stem cell;    Stromal vascular fraction;    Autologous adipose tissue-derived stem cells;    Effectiveness and safety;    Orthopedic applications;   

DOI  :  10.1186/s12929-017-0318-z

 received in 2016-11-24, accepted in 2017-01-25,  发布年份 2017

来源: Springer

【 摘 要 】

Autologous adipose stromal vascular fractions (SVFs) containing adipose tissue-derived stem cells (ASCs) are currently being used in clinical settings for various orthopedic applications for human patients. Due to its potential capability of regenerating cartilage, bone, and tendons, autologous adipose SVFs are being tried in treating patients with osteoarthritis (OA), chondromalacia, meniscus tear, osteonecrosis of the femoral head, and tendon injuries. Here, we have reviewed available human clinical studies with regard to patient applications of autologous adipose SVF containing ASCs, specifically assessing effectiveness and safety in the field of orthopedic disorders. All studies reviewed in this article presents potential benefits of autologous adipose SVF in various orthopedic applications without any serious side effects.

【 授权许可】

CC BY   
© The Author(s). 2017