Glycosylated hemoglobin (HbA1c) levels and clinical outcomes in diabetic patients following coronary artery stenting

Cardiovascular Diabetology

Original Investigation

Seyed Ebrahim Kassaian¹  Mojtaba Salarifar¹  Mohammad Alidoosti¹  Ebrahim Nematipour¹  Saeed Sadeghian¹  Hamidreza Pourhoseini¹  Mohammad Ali Boroumand²  Mohammad Reza Mohajeri-Tehrani³  Elham Hakki⁴  Narges Ramezanpour⁴  Hamidreza Goodarzynejad⁵  Soheil Saadat⁶  Farzad Masoudkabir⁷ 

[1] Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran;Department of Clinical and Surgical Pathology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran;Endocrinology and Metabolism Research Center (EMRC), Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran;Research Department, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran;Research Department, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran;Tehran Heart Center, Karegar Shomali St., Jalal al-Ahmad Cross, 1411713138, Tehran, Iran;Sina Trauma Research Center, Tehran University of Medical Sciences, Tehran, Iran;Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran;

关键词: Diabetes mellitus;    Percutaneous coronary intervention;    Glycaemic control;    Major adverse cardiovascular events;   

DOI  :  10.1186/1475-2840-11-82

 received in 2012-04-11, accepted in 2012-07-01,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundDiabetes has been shown to be independent predictor of restenosis after percutaneous coronary intervention (PCI). The aim of the present study was to investigate whether a pre- and post-procedural glycaemic control in diabetic patients was related to major advance cardiovascular events (MACE) during follow up.MethodsWe evaluated 2884 consecutive patients including 2181 non-diabetic patients and 703 diabetics who underwent coronary stenting. Diabetes mellitus was defined as the fasting blood sugar concentration ≥ 126 mg/dL, or the use of an oral hypoglycemic agent or insulin at the time of admission. Diabetic patients were categorized into two groups based on their mean HbA1c levels for three measurements (at 0, 1, and 6 months following procedure): 291 (41.4%) diabetics with good glycaemic control (HbA1c ≤ 7%) and 412 (58.6%) diabetics with poor glycaemic control (HbA1c > 7%).ResultsThe adjusted risk of MACE in diabetic patients with poor glycaemic control (HbA1c > 7%) was 2.1 times of the risk in non-diabetics (adjusted HR = 2.1, 95% CI: 1.10 to 3.95, p = 0.02). However, the risk of MACE in diabetics with good glycaemic control (HbA1c ≤ 7%) was not significantly different from that of non-diabetics (adjusted HR = 1.33, 95% CI: 0.38 to 4.68, p = 0.66).ConclusionsOur data suggest that there is an association between good glycaemic control to obtain HbA1c levels ≤7% (both pre-procedural glycaemic control and post-procedural) with a better clinical outcome after PCI.

【 授权许可】

Unknown   
© Kassaian et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.