Insulin resistance in Chinese patients with type 2 diabetes is associated with C-reactive protein independent of abdominal obesity

Cardiovascular Diabetology

Original Investigation

Xuanchun Wang¹  Zhaoyun Zhang¹  Yehong Yang¹  Xiaocheng Feng¹  Bin Lu¹  Renming Hu¹  Zhihong Yang¹ 

[1] Department of Endocrinology and Metabolism, HuaShan Hospital, 200040, Shanghai, PR China;Institute of Endocrinology and Diabetology, Fudan University, Shanghai, PR China;

关键词: Body Mass Index;    Obesity;    Insulin Resistance;    Waist Circumference;    Abdominal Obesity;   

DOI  :  10.1186/1475-2840-9-92

 received in 2010-11-07, accepted in 2010-12-19,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThere is debate as to whether the association between C-reactive protein (CRP) and insulin resistance is independent of body fatness, particularly central obesity. Therefore, the association among CRP, insulin resistance and obesity was analyzed in Chinese patients with type 2 diabetes.MethodsThe study included 520 Chinese patients diagnosed with type 2 diabetes with CRP levels not exceeding 10 mg/L. The degree of insulin resistance was determined with the homeostasis model assessment of insulin resistance (HOMA-IR). The CRP levels were categorized into quartiles from the lowest to the highest concentrations (Q1-Q4).ResultsBody mass index (BMI) and waist circumference (WC) were both higher in Q4, Q3 and Q2 than those in Q1. HOMA-IR was higher in Q2, Q3 and Q4 than that in Q1 (Q1 vs Q4, P < 0.001; Q1 vs Q3, P < 0.001; Q1 vs Q2, P = 0.028). Log CRP was significantly correlated with log HOMA-IR (correlation coefficient: 0.230, P < 0.001) and BMI (correlation coefficient: 0.305, P < 0.001) and WC (correlation coefficient: 0.240, P < 0.001) by Spearman correlation analysis. Multiple linear regression analysis adjusting for age, gender and components of metabolic syndrome, log CRP was also independently associated with log HOMA-IR (β coefficient, 0.168; P < 0.001) and WC (β coefficient, 0.131; P = 0.006).ConclusionThese findings showed that insulin resistance was associated with CRP levels independent of abdominal obesity in Chinese patients with type 2 diabetes, suggesting that abdominal obesity could only partly explain the link between subclinical inflammation and insulin resistance.

【 授权许可】

Unknown   
© Lu et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.