A malaria transmission-directed model of mosquito life cycle and ecology

Malaria Journal

Research

Philip A Eckhoff¹ 

[1] Intellectual Ventures Laboratory, 1600 132nd Ave NE, 98004, Bellevue, WA, USA;

关键词: Malaria;    Indoor Residual Spray;    Vector Population;    Entomological Inoculation Rate;    Larval Habitat;   

DOI  :  10.1186/1475-2875-10-303

 received in 2011-07-19, accepted in 2011-10-17,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundMalaria is a major public health issue in much of the world, and the mosquito vectors which drive transmission are key targets for interventions. Mathematical models for planning malaria eradication benefit from detailed representations of local mosquito populations, their natural dynamics and their response to campaign pressures.MethodsA new model is presented for mosquito population dynamics, effects of weather, and impacts of multiple simultaneous interventions. This model is then embedded in a large-scale individual-based simulation and results for local elimination of malaria are discussed. Mosquito population behaviours, such as anthropophily and indoor feeding, are included to study their effect upon the efficacy of vector control-based elimination campaigns.ResultsResults for vector control tools, such as bed nets, indoor spraying, larval control and space spraying, both alone and in combination, are displayed for a single-location simulation with vector species and seasonality characteristic of central Tanzania, varying baseline transmission intensity and vector bionomics. The sensitivities to habitat type, anthropophily, indoor feeding, and baseline transmission intensity are explored.ConclusionsThe ability to model a spectrum of local vector species with different ecologies and behaviours allows local customization of packages of interventions and exploration of the effect of proposed new tools.

【 授权许可】

CC BY   
© Eckhoff; licensee BioMed Central Ltd. 2011