期刊论文详细信息
Biology of Sex Differences
Sex differences in the association between adipose insulin resistance and non-alcoholic fatty liver disease in Chinese adults
Research
Ying Wei1  Jia Liu1  Guang Wang1  Ying Wang2 
[1] Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8, Gongti South Road, Chaoyang District, 100020, Beijing, China;Health Management Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China;
关键词: Sex;    Non-alcoholic fatty liver disease;    Adipose tissue;    Insulin resistance;    Hyperlipidemias;    Menopause;    Age;   
DOI  :  10.1186/s13293-023-00549-0
 received in 2022-12-20, accepted in 2023-09-13,  发布年份 2023
来源: Springer
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【 摘 要 】

BackgroundAdipose insulin resistance (Adipo-IR) is associated with multiple metabolic diseases, including non-alcoholic fatty liver disease (NAFLD). The study aimed to evaluate sex differences in the association between Adipo-IR and NAFLD, and further investigated other potential modifiers.MethodsThis cross-sectional study enrolled adults without diabetes who underwent physical examinations in Beijing Chao-Yang Hospital. We calculated the Adipo-IR index as the product of the fasting insulin and free fatty acid concentration. We categorized Adipo-IR into four groups according to quartiles, using the first interquartile range (Q1) as the reference. Logistic regression was used stratified by the modifiers after adjustment for potential confounders.ResultsThere were 5586 participants in the study, 49.8% (n = 2781) of whom were women and 30.4% (n = 1698) with NAFLD. There was a graded positive association between Adipo-IR and NAFLD, with sex (P = 0.01) and hyperlipidemia (P = 0.02) modifying this association. In the hyperlipidemic women, for one unit increase in log-Adipo-IR, the odds of having NAFLD increased by 385% after adjustment for potential confounders (OR = 4.85, 95%CI 3.54–6.73, P < 0.001). However, it turned out that the odds of having NAFLD increased by 131% (OR = 2.31, 95%CI 1.74–3.11, P < 0.001), 216% (OR = 3.16, 95%CI 2.56–3.93, P < 0.001), 181% (OR = 2.81, 95%CI 1.88–4.28, P < 0.001) in normolipidemic men, hyperlipidemic men, and normolipidemic women, respectively. Similarly, the ORs for the association between Adipo-IR and NAFLD in women with age ≥ 50 years were higher than ORs in women with age < 50 years.ConclusionsThe positive correlation between Adipo-IR and NAFLD was stronger in hyperlipidemic women, compared with normolipidemic or hyperlipidemic men, or normolipidemic women. The association also strengthened for women over 50 years. Treatment strategies targeting Adipo-IR to alleviate NAFLD may be of value, especially in hyperlipidemic women after menopause.

【 授权许可】

CC BY   
© Society for Women's Health Research and BioMed Central Ltd. 2023

【 预 览 】
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Fig. 1

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