Plasma levels of apolipoprotein-E in residents of the European North of Russia

Lipids in Health and Disease

Research

Jon O Odland¹  Anastasiya M Kaneva²  Natalya N Potolitsyna²  Evgeny R Bojko² 

[1] Faculty of Health Sciences, University of Tromso, NO-9037, Tromso, Norge, Norway;Institute of Physiology, Komi Science Center, Ural Branch of Russian Academy of Sciences, Pervomaiskaya av. 50, 167982, Syktyvkar, Russia;

关键词: Apolipoprotein-E;    Lipid metabolism;    Age;    The North;    Adaptation;   

DOI  :  10.1186/1476-511X-12-43

 received in 2013-01-21, accepted in 2013-03-21,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundApolipoprotein-E (apoE) is one of the metabolically active apoproteins and plays an important role in lipid metabolism. However, there are no data on levels of apoE in residents of the North in spite of the fact that specific features of lipid metabolism in the northerners are described. The present work was designed to study plasma levels of apoE in residents of the European North of Russia.MethodsA total of 937 native residents of the European North of Russia (463 men and 474 women) aged 13–60 years were included in the study. ApoE concentrations in the blood plasma were measured by immunoturbidimetric method.ResultsPlasma levels of apoE in residents of the European North of Russia were low. ApoE concentrations below the defined normal values were detected in 57.0% of the men and in 59.2% of the women. The mean plasma levels of apoE did not significantly differ in men and women (2.80 mg/dl vs 2.87 mg/dl). Plasma apoE concentrations in residents of the European North of Russia changed with age. Plasma levels of apoE decreased from 13 to 21 years in men and from 13 to 35 years in women and then increased in both sexes (p < 0.001).ConclusionThe limits of variation of plasma apoE levels in residents of the European North of Russia shift towards lower values. Plasma levels of apoE below normal values were observed in approximately half of investigation subjects.

【 授权许可】

CC BY   
© Kaneva et al.; licensee BioMed Central Ltd. 2013