Identification of ANLN as ETV6 partner gene in recurrent t(7;12)(p15;p13): a possible role of deregulated ANLN expression in leukemogenesis

Molecular Cancer

Letter to the Editor

Paulo Vidal Campregher¹  Nelson Hamerschlak²  Fabio Pires de Souza Santos²  Ricardo Helman²  Elvira Deolinda Rodrigues Pereira Velloso²  Nydia Strachman Bacal²  Fernando Ferreira Costa³  Vincent Miller⁴  Siraj Ali⁴  Jeffrey S. Ross⁵  Mariana Miyagi⁶  Tarcila Santos Datoguia⁶  Evelyn Helena Ascendino da Mata⁶  Welbert de Oliveira Pereira⁶  Bianca Lisboa⁶  Renato Puga⁶ 

[1] Centro de Pesquisa Clinica, IIEP, Hopsital Albert Einstein, Av. Albert Einstein, 627/520, São Paulo, SP, Brazil;Research Institute, Hospital Israelita Albert Einstein, São Paulo, Brazil;Foundation Medicine, Cambridge, MT, USA;Department of Hematology, University of Campinas/Hemocentro - Unicamp, Campinas, Brazil;Department of Hematology, Hospital Israelita Albert Einstein, São Paulo, Brazil;Department of Hematology, University of Campinas/Hemocentro - Unicamp, Campinas, Brazil;Foundation Medicine, Cambridge, MT, USA;Foundation Medicine, Cambridge, MT, USA;Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, NY, USA;Research Institute, Hospital Israelita Albert Einstein, São Paulo, Brazil;

关键词: Leukemia;    Myeloid;    Acute;    Gene fusion;    Translocation;    Genetic;   

DOI  :  10.1186/s12943-015-0471-5

 received in 2015-08-04, accepted in 2015-11-15,  发布年份 2015

来源: Springer

【 摘 要 】

The ETV6 gene encodes an ETS family transcription factor that is involved in a myriad of chromosomal rearrangements found in hematological malignancies and other neoplasms. A recurrent ETV6 translocation, previously described in patients with acute myeloid leukemia (AML) (Genes Chromosomes Cancer 51:328–337,2012, Leuk Res 35:e212-214, 2011), whose partner has not been identified is t(7;12)(p15;p13). We herein report that the t(7;12)(p15;p13) fuses ETV6 to ANLN, a gene not previously implicated in the pathogenesis of hematological malignancies, and we demonstrate that this translocation leads to high expression of the fusion transcript in the myeloid and lymphoid lineages.

【 授权许可】

CC BY   
© Campregher et al. 2015