Leucine supplementation combined with resistance exercise improves the plasma lipid profile of dexamethasone-treated rats

Lipids in Health and Disease

Short Report

Claudia R da Luz¹  Kerolyn S Valente¹  Humberto Nicastro¹  Daniela F S Chaves¹  William das Neves¹  Antonio H Lancha¹ 

[1] Laboratory of Applied Nutrition and Metabolism, Physical Education and Sports School, University of São Paulo, São Paulo, SP, Brazil;

关键词: Branched-chain amino acids;    glucocorticoid;    lipid profile;    exercise;   

DOI  :  10.1186/1476-511X-11-7

 received in 2011-12-07, accepted in 2012-01-11,  发布年份 2012

来源: Springer

【 摘 要 】

The impact of leucine supplementation and resistance exercise (RE) on plasma lipid profile was evaluated in adult rats treated with dexamethasone, an experimental model of dyslipidemia. Total cholesterol did not differ among groups. Furthermore, leucine supplementation did not promote improvement in the plasma total cholesterol and LDL-c of the animals. However, plasma TG and VLDL-c were significantly decreased and HDL-c increased after 7 days of leucine supplementation combined with RE. In conclusion, leucine supplementation combined with RE, but not isolated, improved the plasma lipid profile of dexamethasone-induced dyslipidemic rats.

【 授权许可】

CC BY   
© Nicastro et al; licensee BioMed Central Ltd. 2012