Leucine supplementation combined with resistance exercise improves the plasma lipid profile of dexamethasone-treated rats

Lipids in Health and Disease

Antonio H Lancha¹  Kerolyn S Valente¹  William das Neves¹  Daniela FS Chaves¹  Claudia R da Luz¹  Humberto Nicastro¹ 

[1] Laboratory of Applied Nutrition and Metabolism, Physical Education and Sports School, University of São Paulo - São Paulo, SP, Brazil

关键词: exercise;    lipid profile;    glucocorticoid;    Branched-chain amino acids;   

Others  :  1160379
DOI  :  10.1186/1476-511X-11-7

 received in 2011-12-07, accepted in 2012-01-11,  发布年份 2012

【 摘 要 】

The impact of leucine supplementation and resistance exercise (RE) on plasma lipid profile was evaluated in adult rats treated with dexamethasone, an experimental model of dyslipidemia. Total cholesterol did not differ among groups. Furthermore, leucine supplementation did not promote improvement in the plasma total cholesterol and LDL-c of the animals. However, plasma TG and VLDL-c were significantly decreased and HDL-c increased after 7 days of leucine supplementation combined with RE. In conclusion, leucine supplementation combined with RE, but not isolated, improved the plasma lipid profile of dexamethasone-induced dyslipidemic rats.

【 授权许可】

   
2012 Nicastro et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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