Leprosy ulcers in a rural hospital of Ethiopia: pattern of aerobic bacterial isolates and drug sensitivities

Annals of Clinical Microbiology and Antimicrobials

Research

María C Bellón¹  Fernando Mateos¹  Tafese Yohannes²  Gabre Tisisano²  Francisco Reyes²  Ramón Pérez-Tanoira³  José M Ramos⁴  Cristina García-García⁵  Miguel Górgolas⁶  Laura Prieto-Pérez⁶ 

[1] Department of Internal Medicine, Hospital General Universitario de Albacete, Albacete, Spain;Department of Medicine and Laboratory, Gambo Rural General Hospital, Kore, West-Arsi, Gambo, Ethiopia;Department of Medicine and Laboratory, Gambo Rural General Hospital, Kore, West-Arsi, Gambo, Ethiopia;Department of Clinical Microbiology, Fundacin Jimnez Daz, Madrid, Spain;Departament of Medicine, Universidad Autonoma de Madrid, Madrid, Spain;Department of Medicine and Laboratory, Gambo Rural General Hospital, Kore, West-Arsi, Gambo, Ethiopia;Department of Internal Medicine, Hospital General Universitario de Alicante, Alicante, Spain;Department of Medicine, Universidad Miguel Hernndez, San Juan Campus, C Pintor Baeza s/n, 03010, Alicante, Spain;Department of Medicine and Laboratory, Gambo Rural General Hospital, Kore, West-Arsi, Gambo, Ethiopia;Department of Internal Medicine, Hospital General Virgen de la Luz, Cuenca, Spain;Department of Medicine and Laboratory, Gambo Rural General Hospital, Kore, West-Arsi, Gambo, Ethiopia;Division of Infectious Diseases, Fundacion Jimnez Daz, Madrid, Spain;Departament of Medicine, Universidad Autonoma de Madrid, Madrid, Spain;

关键词: Bacterial isolation;    Chronic ulcer;    Leprosy;    Pathogens;    Susceptibility testing;   

DOI  :  10.1186/s12941-014-0047-z

 received in 2014-07-22, accepted in 2014-09-07,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundPlantar ulcers, which commonly occur in leprosy patients, tend to recur increasing physical disability. The aim of this study is to identify both the bacteriological profile of these ulcers and the antibiotic susceptibility of the isolated bacteria.Materials and methods68 leprosy patients with chronic ulcers attending the in-patient department of Gambo General Hospital, West Arsi, were included in this study. Proper sample collection, inoculation on culture media, and final identification using biochemical methods were undertaken.Results66 patients (97.1%) had a positive culture. A total of 81 microorganisms were isolated. Multiple organisms (two or more) were isolated in 15 (22.7% out of positive culture) patients. The main isolation was Proteus spp (30.9%), followed by Escherichia coli (21.0%), Staphylococcus aureus (18.5%) and Pseudomonas aeruginosa (9.9%). In the total number of the isolated bacteria, the antibiotics with less resistance were gentamicin (18.5%), fosfomycin (22.2%) cefoxitin (24.7%), ceftriaxone (25.9%) ciprofloxacin (25.9%), and amoxicillin-clavulanic acid (28.49%).ConclusionThe bacteriological study of plantar ulcers of leprosy patients revealed Enterobacteriaceae and S. aureus as the main pathogens involved in such infections. The results of this study may guide empirical therapy in a rural area hospital where culture and susceptibility testing facilities are scarce.

【 授权许可】

CC BY   
© Ramos et al.; licensee BioMed Central Ltd. 2014