Helping women to good health: breast cancer, omega-3/omega-6 lipids, and related lifestyle factors

BMC Medicine

Commentary

Patricia Salen¹  Michel de Lorgeril¹ 

[1] Laboratoire TIMC-IMAG, CNRS UMR 5525, PRETA Cœur and Nutrition, and Faculté de Médecine, Université Joseph Fourier, Grenoble, France;

关键词: Polyphenols;    Organic foods;    Endocrine disruptors;    Insulin;    Diabetes;    Cholesterol;    Hypertension;    Mediterranean diet;   

DOI  :  10.1186/1741-7015-12-54

 received in 2014-02-26, accepted in 2014-02-26,  发布年份 2014

来源: Springer

【 摘 要 】

In addition to genetic predisposition and sex hormone exposure, physical activity and a healthy diet play important roles in breast cancer (BC). Increased intake of omega-3 fatty acids (n-3) associated with decreased omega-6 (n-6), resulting in a higher n-3/n-6 ratio compared with the western diet, are inversely associated with BC risk, as shown by Yang et al. in their meta-analysis in BMC Cancer. High consumption of polyphenols and organic foods increase the n-3/n-6 ratio, and in turn may decrease BC risk. Intake of high fiber foods and foods with low glycemic index decreases insulin resistance and diabetes risk, and in turn may decrease BC risk. The modernized Mediterranean diet is an effective strategy for combining these recommendations, and this dietary pattern reduces overall cancer risk and specifically BC risk. High-risk women should also eliminate environmental endocrine disruptors, including those from foods. Drugs that decrease the n-3/n-6 ratio or that are suspected of increasing BC or diabetes risk should be used with great caution by high-risk women and women wishing to decrease their BC risk.Please see related article: http://www.biomedcentral.com/1471-2407/14/105/abstract.

【 授权许可】

CC BY   
© de Lorgeril and Salen; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.