Type 2 diabetes progression in an adult Ugandan population with new-onset diabetes: an observational prospective study

BMC Primary Care

Research

William Lumu¹  Isaac Sekitoleko²  Moffat J. Nyirenda³  Davis Kibirige⁴ 

[1] Department of Medicine, Mengo Hospital, Kampala, Uganda;Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Non-Communicable Diseases Program, Entebbe, Uganda;Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Non-Communicable Diseases Program, Entebbe, Uganda;Department of Non-Communicable Diseases Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK;Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Non-Communicable Diseases Program, Entebbe, Uganda;Department of Non-Communicable Diseases Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK;Department of Medicine, Uganda Martyrs Hospital Lubaga, Kampala, Uganda;

关键词: Adult patients;    New-onset type 2 diabetes;    Short-term diabetes progression;    Sub-Saharan Africa;    Uganda;   

DOI  :  10.1186/s12875-023-02169-4

 received in 2023-02-16, accepted in 2023-10-03,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe rate of progression of type 2 diabetes following diagnosis varies across individuals and populations. Studies investigating the progression of type 2 diabetes in adult African populations with newly diagnosed diabetes are limited. We aimed to investigate the prevalence and predictors of short-term (one year) diabetes progression in an adult Ugandan population with new-onset type 2 diabetes (type 2 diabetes diagnosed in < 3 months) initiated on oral hypoglycaemic agents (OHA).MethodsTwo hundred and seven adult participants with type 2 diabetes diagnosed within the previous three months were followed up for 12 months. We investigated the association of specific demographic, clinical, and metabolic characteristics, and short-term diabetes progression (defined as glycated haemoglobin or HbA1c ≥ 8% on ≥ 2 OHA and/or treatment intensification).ResultsOne hundred sixteen participants (56%) completed the follow-up period. Sixty-four participants (55.2%, 95% CI 45.7–64.4) showed evidence of diabetes progression during the 12-month period of follow-up. An HbA1c ≥ 8% on ≥ 2 OHA and treatment intensification were noted in 44.8% and 29.3% of the participants, respectively. On multivariate analysis, only the female gender (AOR 3.2, 95% CI 1.1–9.2, p = 0.03) was noted to be independently associated with short-term diabetes progression.ConclusionShort-term diabetes progression was relatively common in this study population and was independently associated with the female gender. Early intensified diabetes therapy in adult Ugandan female patients with new-onset type 2 diabetes should be emphasised to avert rapid short-term diabetes progression.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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