Coffee and tea consumption in relation to inflammation and basal glucose metabolism in a multi-ethnic Asian population: a cross-sectional study

Nutrition Journal

Research

Cynthia H Chen¹  Nasheen Naidoo¹  Rob M van Dam²  Kee Seng Chia³  Jeannette Lee³  Wang Xu³  E Shyong Tai⁴  Salome A Rebello⁵ 

[1] Center for Molecular Epidemiology, National University of Singapore, #05-02, 28 Medical Drive, 117456, Singapore;Department of Epidemiology and Public Health and Medicine, Yong Loo Lin School of Medicine, National University of Singapore Block MD3 #03-17, 16, Medical Drive, Singapore. 117597 and Department of Nutrition, Harvard School of Public Health, 02115, Boston, Massachusetts, USA;Department of Epidemiology and Public Health, National University of Singapore, Yong Loo Lin School of Medicine, 16 Medical Drive, 117597, Singapore;Department of Medicine, National University of Singapore, 1E, Kent Ridge Road, NUHS Tower Block Level 10, 119228, Singapore;Life Sciences Institute, Centre for Life Sciences, National University of Singapore, 05-02, 28 Medical Drive, 117456, Singapore;

关键词: Coffee Consumption;    Adiponectin Concentration;    Coffee Intake;    Total Adiponectin;    High Molecular Weight Adiponectin;   

DOI  :  10.1186/1475-2891-10-61

 received in 2011-02-01, accepted in 2011-06-02,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundHigher coffee consumption has been associated with a lower risk of type 2 diabetes in cohort studies, but the physiological pathways through which coffee affects glucose metabolism are not fully understood. The aim of this study was to evaluate the associations between habitual coffee and tea consumption and glucose metabolism in a multi-ethnic Asian population and possible mediation by inflammation.MethodsWe cross-sectionally examined the association between coffee, green tea, black tea and Oolong tea consumption and glycemic (fasting plasma glucose, HOMA-IR, HOMA-beta, plasma HbA1c) and inflammatory (plasma adiponectin and C-reactive protein) markers in a multi-ethnic Asian population (N = 4139).ResultsAfter adjusting for multiple confounders, we observed inverse associations between coffee and HOMA-IR (percent difference: - 8.8% for ≥ 3 cups/day versus rarely or never; Ptrend = 0.007), but no significant associations between coffee and inflammatory markers. Tea consumption was not associated with glycemic markers, but green tea was inversely associated with plasma C-reactive protein concentrations (percent difference: - 12.2% for ≥ 1 cup/day versus < 1 cup/week; Ptrend = 0.042).ConclusionsThese data provide additional evidence for a beneficial effect of habitual caffeinated coffee consumption on insulin sensitivity, and suggest that this effect is unlikely to be mediated by anti-inflammatory mechanisms.

【 授权许可】

Unknown   
© Rebello et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.