Cardiovascular Diabetology | |
Total and high molecular weight adiponectin have similar utility for the identification of insulin resistance | |
Original Investigation | |
Ivette Cruz-Bautista1  Olimpia Arellano-Campos1  Francisco J Gomez-Perez1  Roopa Mehta1  Paloma Almeda-Valdes1  Mariana Navarrete-Lopez1  Daniel Cuevas-Ramos1  Carlos A Aguilar-Salinas1  | |
[1] Departamento de Endocrinología y Metabolismo Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", 14000 México D.F, México; | |
关键词: Insulin Resistance; Receiver Operator Characteristic Curve; Adiponectin Level; Metabolic Disturbance; Adiponectin Concentration; | |
DOI : 10.1186/1475-2840-9-26 | |
received in 2010-04-02, accepted in 2010-06-23, 发布年份 2010 | |
来源: Springer | |
【 摘 要 】
BackgroundInsulin resistance (IR) and related metabolic disturbances are characterized by low levels of adiponectin. High molecular weight adiponectin (HMWA) is considered the active form of adiponectin and a better marker of IR than total adiponectin. The objective of this study is to compare the utility of total adiponectin, HMWA and the HMWA/total adiponectin index (SA index) for the identification of IR and related metabolic conditions.MethodsA cross-sectional analysis was performed in a group of ambulatory subjects, aged 20 to 70 years, in Mexico City. Areas under the receiver operator characteristic (ROC) curve for total, HMWA and the SA index were plotted for the identification of metabolic disturbances. Sensitivity and specificity, positive and negative predictive values, and accuracy for the identification of IR were calculated.ResultsThe study included 101 men and 168 women. The areas under the ROC curve for total and HMWA for the identification of IR (0.664 vs. 0.669, P = 0.74), obesity (0.592 vs. 0.610, P = 0.32), hypertriglyceridemia (0.661 vs. 0.671, P = 0.50) and hypoalphalipoproteinemia (0.624 vs. 0.633, P = 0.58) were similar. A total adiponectin level of 8.03 μg/ml was associated with a sensitivity of 57.6%, a specificity of 65.9%, a positive predictive value of 50.0%, a negative predictive value of 72.4%, and an accuracy of 62.7% for the diagnosis of IR. The corresponding figures for a HMWA value of 4.25 μg/dl were 59.6%, 67.1%, 51.8%, 73.7% and 64.2%.The area under the ROC curve of the SA index for the identification of IR was 0.622 [95% CI 0.554-0.691], obesity 0.613 [95% CI 0.536-0.689], hypertriglyceridemia 0.616 [95% CI 0.549-0.683], and hypoalphalipoproteinemia 0.606 [95% CI 0.535-0.677].ConclusionsTotal adiponectin, HMWA and the SA index had similar utility for the identification of IR and metabolic disturbances.
【 授权许可】
Unknown
© Almeda-Valdes et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
【 预 览 】
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