Eight week exposure to a high sugar high fat diet results in adiposity gain and alterations in metabolic biomarkers in baboons (Papio hamadryas sp.)

Cardiovascular Diabetology

Original Investigation

J Michael Proffitt¹  V Saroja Voruganti¹  Paul B Higgins¹  Vicki Mattern¹  Karin Haack¹  Shelley A Cole¹  Anthony G Comuzzie²  Raul A Bastarrachea²  Juan Carlos Lopez-Alvarenga³  M Elizabeth Tejero⁴  Maggie Garcia-Forey⁵  Robert E Shade⁶ 

[1] Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA;Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA;Southwest National Primate Research Center, San Antonio, Texas, USA;Hospital General de Mexico, Mexico City, Mexico;Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA;INMEGEN, Mexico City, Mexico;Southwest National Primate Research Center, San Antonio, Texas, USA;Southwest National Primate Research Center, San Antonio, Texas, USA;INMEGEN, Mexico City, Mexico;Southwest National Primate Research Center, San Antonio, Texas, USA;Southwest Foundation for Biomedical Research, San Antonio, Texas, USA;

关键词: Adiponectin Concentration;    Trunk Region;    High Fructose Corn Syrup;    Body Composition Assessment;    Sweetened Water;   

DOI  :  10.1186/1475-2840-9-71

 received in 2010-07-25, accepted in 2010-10-29,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundBaboons (Papio hamadryas Sp.) develop features of the cardiometabolic syndrome and represent a clinically-relevant animal model in which to study the aetiology of the disorder. To further evaluate the baboon as a model for the study of the cardiometabolic syndrome, we developed a high sugar high fat diet and hypothesized that it could be used to induce adiposity gain and affect associated circulating biomarkers.MethodsWe developed a diet enriched with monosaccharides and saturated fatty acids that was composed of solid and liquid energy sources. We provided a group of baboons (n = 9) ad libitum access to this diet for 8 weeks. Concurrently, a control group (n = 6) was maintained with ad libitum access to a low sugar low fat baseline diet and normal water for 8 weeks. Body composition was determined by dual-energy X-ray absorptiometry and circulating metabolic biomarkers were measured using standard methodology before and after the 8 week study period.ResultsNeither body composition nor circulating biomarkers changed in the control group. Following the 8 weeks, the intervention group had a significant increase in fat mass (1.71 ± 0.98 vs. 3.23 ± 1.70 kg, p = 0.004), triglyceride (55 ± 13 vs. 109 ± 67 mg/dL, p = 0.006,), and leptin (1.19 ± 1.40 vs. 3.29 ± 2.32 ng/mL, p = 0.001) and a decline in adiponectin concentrations (33530 ± 9744 vs. 23330 ± 7863 ng/mL, p = 0.002). Percentage haemoglobin A1C (4.0 ± 0.3 vs. 6.0 ± 1.4, p = 0.002) also increased in the intervention group.ConclusionsOur findings indicate that when exposed to a high sugar high fat diet, young adult male baboons develop increased body fat and triglyceride concentrations, altered adipokine concentrations, and evidence of altered glucose metabolism. Our findings are in keeping with observations in humans and further demonstrate the potential utility of this highly clinically-relevant animal model for studying diet-induced metabolic dysregulation.

【 授权许可】

Unknown   
© Higgins et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.