Lipids in Health and Disease | |
Micronutrients-fortified rapeseed oil improves hepatic lipid accumulation and oxidative stress in rats fed a high-fat diet | |
Research | |
Chang Chen1  Hui Gao2  Xiaoqi Zhou2  Qianchun Deng3  Jin’e Yang3  Fenghong Huang3  Qingde Huang3  Jiqu Xu3  Zhengyang Wan4  Jing Ma4  | |
[1] Department of Gastroenterology, The No.1 Hospital of Yichang, 2 Jiefang Road, 443000, Yichang, People’s Republic of China;Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, 430030, Wuhan, People’s Republic of China;Department of Product Processing and Nutriology, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, 430062, Wuhan, People’s Republic of China;Hubei Key Laboratory of Lipid Chemistry and Nutrition, 2 Xudong Second Road, 430062, Wuhan, People’s Republic of China;Yichang Center for Disease Control and Prevention, 3 Dalian Road, 443000, Yichang, People’s Republic of China; | |
关键词: Rapeseed oil; Polyphenols; Tocopherols; Phytosterols; Lipid accumulation; Oxidant stress; | |
DOI : 10.1186/1476-511X-12-28 | |
received in 2013-01-05, accepted in 2013-02-28, 发布年份 2013 | |
来源: Springer | |
【 摘 要 】
Intake of high-fat diet is associated with increased fatty livers. Hepatic lipid accumulation and oxidative stress are key pathophysiological mechanisms in this disease. Micronutrients polyphenols, tocopherols and phytosterols in rapeseed exert potential benefit to hepatoprotection, but most of these micronutrients are removed by the traditional refining process. The purpose of the present study was to determine whether rapeseed oil fortified with these micronutrients can decrease hepatic lipid accumulation and oxidative stress induced by high-fat diet. Sprague–Dawley rats received rodent diet contained 20% fat whose source was refined rapeseed oil (RRO) or fortified RRO with low, middle and high quantities of these micronutrients for 10 weeks. Intake of RRO caused a remarkable hepatic steatosis. Micronutrients supplementation was effective in reducing steatosis as well as total triglyceride and total cholesterol contents in liver. These micronutrients also significantly increased hepatic antioxidant defense capacities, as evaluated by the significant elevation in the activities of SOD and GPx as well as the level of GSH, and the significant decline in lipid peroxidation. These findings suggest that rapeseed oil fortified with micronutrients polyphenols, tocopherols and phytosterols may contribute to prevent fatty livers such as nonalcoholic fatty liver disease by ameliorating hepatic lipid accumulation and oxidative stress.
【 授权许可】
Unknown
© Xu et al; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
【 预 览 】
Files | Size | Format | View |
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RO202311107695756ZK.pdf | 715KB | download |
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