Rapeseed oil fortified with micronutrients reduces atherosclerosis risk factors in rats fed a high-fat diet

Lipids in Health and Disease

Research

Xiaoqi Zhou¹  Qianchun Deng²  Jin'e Yang²  Fenghong Huang²  Qingde Huang²  Jiqu Xu² 

[1] Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, 430030, Wuhan, P.R. China;Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, 430062, Wuhan, P.R. China;

关键词: Rapeseed oil;    Polyphenols;    Tocopherols;    Phytosterols;    Atherosclerosis;    Oxidant stress;    Plasma lipids;    Inflammation;   

DOI  :  10.1186/1476-511X-10-96

 received in 2011-05-10, accepted in 2011-06-13,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundMicronutrients polyphenols, tocopherols and phytosterols in rapeseed exert potential benefit to cardiovascular system, but most of these micronutrients are removed by the refining process. The aim of this study was to determine the effect of rapeseed oil fortified with these micronutrients on the atherosclerosis risk factors in rats fed a high-fat diet.MethodsThe rodent diet contained 20% fat whose source was refined rapeseed oil (RRO) or fortified refined rapeseed oil with low, middle and high quantities of these micronutrients (L-, M- and H-FRRO). Forty male SD rats were divided into four groups. One group received RRO diet and other groups received L-, M- and H-FRRO diet for 10 weeks.ResultsMicronutrients supplementation significantly increased plasma antioxidant defense capacities, as evaluated by the significant elevation in the activities of GPx, CAT and SOD as well as the level of GSH, and the significant decline in lipid peroxidation. These micronutrients also reduced the plasma contents of TG, TC and LDL-C and increased the ratio of HDL-C/LDL-C. In addition, in parallel with the enhancement of these micronutrients, plasma levels of IL-6 and CRP declined remarkably.ConclusionRapeseed oil fortified with micronutrients polyphenols, tocopherols and phytosterols may contribute to prevent atherogenesis by ameliorating plasma oxidative stress, lipid profile and inflammation.

【 授权许可】

Unknown   
© Xu et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.