Salvage surgery for neck residue or recurrence of nasopharyngeal carcinoma after primary radiotherapy: options of surgical methods and regions

World Journal of Surgical Oncology

Research

Liang Guo¹  Jian-lin Lou¹  Su-zhan Zhang²  Sheng-ye Wang³  Jianxiang Chen⁴ 

[1] Department of Head and Neck Surgery, Zhejiang Cancer Hospital, 310022, Hangzhou, People’s Republic of China;Department of Oncology, Second Affiliated Hospital, School of Medicine, Zhejiang University, 88# Jiefang Road, 310009, Hangzhou, China;Department of Oncology, Second Affiliated Hospital, School of Medicine, Zhejiang University, 88# Jiefang Road, 310009, Hangzhou, China;Department of Radiation Oncology, Zhejiang Cancer Hospital, 310022, Hangzhou, People’s Republic of China;Department of Radiation Oncology, Zhejiang Cancer Hospital, 310022, Hangzhou, People’s Republic of China;

关键词: Nasopharyngeal carcinoma;    Salvage surgery;    Residual;    Recurrence;    Neck dissection;   

DOI  :  10.1186/s12957-016-0822-8

 received in 2015-11-29, accepted in 2016-02-29,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundSalvage surgery has been recommended as the approach of choice for neck residue or recurrence of nasopharyngeal carcinoma (NPC) after primary radiotherapy (RT). This study aimed to assess the outcome and prognostic factors, options for different surgical methods, and the extent of neck dissection (ND) for patients.MethodsNPC patients who had undergone RT and received salvage surgery for neck residue or recurrence from January 2001 to December 2011 were retrospectively analyzed. The overall survival (OS) rate was calculated by Kaplan-Meier method, and prognostic factors were determined by log-rank test and Cox regression analysis.ResultsIn 153 cases, 96 cases have level I dissections. The metastasis rate was 20/153 (13.07 %) for level I metastasis and 7/153 (4.58 %) for parotid gland cases. The 3- and 5-year OS rate was 57.2 and 40.6 %, respectively, and median survival time was 49 months. By univariate analysis, the age, rN staging, size of lymph nodes (LN), extra-capsular spread (ECS), and surgical procedure were significant prognostic factors. By multivariable analysis, the age, rN staging, and size of LN were significant prognostic factors.ConclusionsSalvage surgery is effective for neck failure of NPC after primary treatment, but patients with age >50 years, stage rN3, or LN >6 cm have poor prognosis.

【 授权许可】

CC BY   
© Wang et al. 2016