Hybrid gold-iron oxide nanoparticles as a multifunctional platform for biomedical application

Journal of Nanobiotechnology

Research

Craig McDougall¹  Yue Min²  Mariana Gueorguieva²  Alfred Cuschieri²  Alexander Volovick²  Andreas Melzer²  Paul Prentice²  Clare Hoskins²  Zhigang Wang²  Lijun Wang³ 

[1] Division of Electronic Engineering and Physics, University of Dundee, DD1 4HN, Nethergate, Dundee, UK;Institute for Medical Science and Technology (IMSaT), University of Dundee, Wilson House, 1 Wurzburg Loan, DD2 1FD, Dundee, UK;Institute for Medical Science and Technology (IMSaT), University of Dundee, Wilson House, 1 Wurzburg Loan, DD2 1FD, Dundee, UK;Institute for Medical Science and Technology (IMSaT), University of Dundee, Wilson House, 1 Wurzburg Loan, DD2 1FD, Dundee, UK;

关键词: Magnetic nanoparticles;    Gold nano-shells;    Magnetic resonance imaging;    Surface plasmon resonance;    Multifunctional nanoparticles;   

DOI  :  10.1186/1477-3155-10-27

 received in 2012-02-09, accepted in 2012-06-06,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundIron oxide nanoparticles (IONPs) have increasing applications in biomedicine, however fears over long term stability of polymer coated particles have arisen. Gold coating IONPs results in particles of increased stability and robustness. The unique properties of both the iron oxide (magnetic) and gold (surface plasmon resonance) result in a multimodal platform for use as MRI contrast agents and as a nano-heater.ResultsHere we synthesize IONPs of core diameter 30 nm and gold coat using the seeding method with a poly(ethylenimine) intermediate layer. The final particles were coated in poly(ethylene glycol) to ensure biocompatibility and increase retention times in vivo. The particle coating was monitored using FTIR, PCS, UV–vis absorption, TEM, and EDX. The particles appeared to have little cytotoxic effect when incubated with A375M cells. The resultant hybrid nanoparticles (HNPs) possessed a maximal absorbance at 600 nm. After laser irradiation in agar phantom a ΔT of 32°C was achieved after only 90 s exposure (50 μgmL-1). The HNPs appeared to decrease T2 values in line with previously clinically used MRI contrast agent Feridex®.ConclusionsThe data highlights the potential of these HNPs as dual function MRI contrast agents and nano-heaters for therapies such as cellular hyperthermia or thermo-responsive drug delivery.

【 授权许可】

Unknown   
© Hoskins et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.